Drug Shows Promise Against Advanced Form of Lung Cancer

Armen Hareyan's picture

Advanced Lung Cancer Drug

Results of a multi-center clinical study of a drug currently approved for treatment of kidney cancer indicate that it may also be effective for people with recurrent and advanced lung cancer.

The findings of this phase-2 clinical trial will be presented at the American Society of Clinical Oncology (ASCO) meetings in Atlanta on Sunday (June 4).


Dr. Mark A. Socinski, associate professor of medicine at the University of North Carolina at Chapel Hill and a clinical faculty member of the UNC Lineberger Comprehensive Cancer Center, is the study's principal investigator. Socinski said the activity data on Pfizer's oral drug, sunitinib malate, appears "very similar" to that of other currently approved agents for non-small cell lung cancer.

Another drug, Avastin, keeps new blood vessels from forming and has been shown to help people with advanced lung cancer live longer when it was given along with chemotherapy.

Sunitinib, which is also an anti-angiogenic agent, interferes with a tumor cell's ability to develop new blood vessels. It acts on a molecular level by inhibiting an enzyme