Blood pressure drug shows potential as lung cancer treatment
Lung Cancer Treatment
A hormone that is important in the control of blood pressure also shrinks lung cancer tumors in mice, suggesting a new way to prevent or treat the deadly cancer, according to scientists at Wake Forest University School of Medicine.
Reporting in the journal Cancer Research, the scientists said that in mice treated with the hormone, angiotensin-(1-7), tumor volume decreased by 30 percent. In mice that did not receive the treatment, the tumor size more than doubled.
Patricia E. Gallagher, Ph.D., and E. Ann Tallant, Ph.D., senior researchers on the project, had previously reported a similar effect in lung cancer cells studied in the laboratory.
"The current study is the first demonstration of the effect in animals," said Tallant. "Taken together, the two studies suggest a novel treatment for lung cancer, a disease that kills an estimated 170,000 Americans each year."
Wake Forest's Comprehensive Cancer Center will begin studies of the hormone in cancer patients.
"We hope that our clinical trials of angiotensin-(1-7) will lead to the identification of an effective new cancer treatment for our patients," said Frank M. Torti, M.D., M.P.H., director of the Cancer Center, which helped fund the early development of angiotensin (1-7) as an anticancer treatment.
Lung cancer is the leading cause of death in developed countries, accounting for about 170,000 new cases each year in the U.S. In almost two-thirds of cases, the cancer has spread to the lymph nodes by the time of diagnosis, reducing the chances of successful treatment. The five-year survival rate for lung cancer is about 14 percent, the researchers said.
"This grim prognosis indicates a continued need for novel treatment approaches to reduce lung cancer deaths," said Gallagher.
The idea to evaluate the effects of angiotensin-(1-7) on lung cancer came from studies observing that rates of lung cancer were lower in people whose high blood pressure was treated with angiotensin-converting enzyme (ACE) inhibitors. These drugs, which include Capoten