Scientists Discover New Breast Cancer Risk Gene
BRIP1 Breast Cancer Gene
Women with a faulty version of a gene called BRIP1 have an increased risk of developing breast cancer, according to the results of a Cancer Research UK funded study revealed at the National Cancer Research Institute (NCRI) cancer conference and published in today's Nature Genetics.
Scientists from The Institute of Cancer Research studied the BRIP1 gene in 1212 women with breast cancer who had a family history of the disease that was not due to the known breast cancer genes, BRCA1 or BRCA2. They compared these women to 2081 healthy people. They found nine BRIP1 faults (mutations) in the breast cancer patients but only two in the healthy individuals. This indicates that the gene is linked to breast cancer more often than would be expected by chance.
The team worked out that carrying a faulty version of BRIP1 doubled a women's risk of the disease