Sex differences and rheumatoid arthritis
Characterized by chronic synovial tissue inflammation, increasing erosions of cartilage and bone, and eventual destruction of joints, rheumatoid arthritis (RA) is a complex and confounding autoimmune disease. It is associated with a variety of genetic and environmental factors and known to strike women about three times as frequently as men. A major obstacle to investigating this clear sex bias has been the lack of a laboratory rat or mouse that mimics human RA. Until now.
Researchers at the Mayo Clinic have produced a new breed of transgenic mice with autoimmune responses similar to human