Lower Estrogen Levels Are A Risk Factor for Knee Osteoarthritis

Armen Hareyan's picture

Knee Osteoarthritis Treatment

Osteoarthritis, which usually develops between the ages of 40 and 50, is more prevalent in women. It is thought that sex hormones may play a role in developing the disease, since they can be involved in inflammation of the tissues affected by it. A study published in the August 2006 issue of Arthritis & Rheumatism examined estradiol, the primary estrogen in premenopausal and early perimenopausal women, along with two of the hormones into which it breaks down, to determine if their levels are associated with an increased risk of developing osteoarthritis (OA) in women.

Led by MaryFran R. Sowers of the University of Michigan in Ann Arbor, MI, the study included 842 premenopausal or perimenopausal women from the Southeast Michigan Arthritis Cohort. The women had annual X-rays of both knees along with analysis of blood levels of estradiol and urine levels of 2-hydroxyestrone and 16