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Drug Clinical Trials

Sequential R-CHOP, Ibritumomab Tiuxetan Regimen Produces Impressive Survival Rates

Results of an investigator-sponsored trial of the investigational regimen consolidating rituximab-CHOP with 90Yttrium Ibritumomab Tiuxetan radioimmunotherapy in high risk, elderly patients with previously untreated high-intermediate and high risk diffuse large B-cell lymphoma are promising.

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ViroPharma Completes Study Of Maribavir In Stem Cell Transplant Patients

ViroPharma Incorporated completed enrollment in its pivotal Phase 3 study of maribavir in stem cell transplant patients. This international Phase 3 study is evaluating the efficacy, safety and tolerability of prophylactic use of maribavir administered orally for up to 12 weeks for the prevention of cytomegalovirus (CMV) disease in recipients of allogeneic stem cell transplants (SCT). The study also will evaluate the pharmacokinetics of maribavir in this subject population. It is being conducted in 90 transplant centers in the U.S., Canada, and Europe.

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Data Shows Higher Overall Healing In Erosive Esophagitis Patients

TAP Pharmaceutical Products reported results from three pivotal Phase 3 studies evaluating investigational new drug TAK-390MR, the first proton pump inhibitor with an innovative dual delayed release technology, in healing patients with erosive esophagitis and in maintenance of healed EE.

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Pharmasset Commences Dosing R7128 For Chronic Hepatitis C Treatment

Pharmasset has commenced dosing two additional cohorts of a 4-week Phase 1 study of R7128 in combination with Pegasys plus Copegus in both treatment-naive and treatment-experienced patients chronically-infected with hepatitis C virus genotypes 1, 2 and 3.

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Trial Investigates REOLYSIN In Combination With Paclitaxel, Carboplatin

Oncolytics Biotech has received a letter of approval from MHRA for its CTA to begin a Phase II clinical trial using intravenous administration of REOLYSIN in combination with paclitaxel and carboplatin in patients with advanced head and neck cancers.

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Studies Showed Higher SVR For PEGASYS Plus Ribavirin Successful In Treating Hepatitis C

Roche's three studies indicate that chronic hepatitis C patients who received PEGASYS plus ribavirin had a greater chance of achieving a sustained virological response than patients on peginterferon alfa-2b.

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PTC Therapeutics Initiates Trial Of PTC124 In Muscular Dystrophy

PTC Therapeutics initiates an international pivotal trial of PTC124 in patients with Duchenne/Becker muscular dystrophy (DMD/BMD) due to a nonsense mutation. The primary objective of this registration-directed Phase 2b trial is to demonstrate the efficacy of PTC124 as measured by improvements in the walking ability of patients with this progressive genetic disease.

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MMC Completes Studies For Integrated Hematology, Automated Diabetes Testing Solution

Sysmex America announced the successful completion of Mercy Medical Center's (Canton, OH) beta studies for its integrated hematology and A1C automation solution. This first-of-kind solution, which combines the Sysmex HST-N hematology automation platform and the Bio-Rad Laboratories, Inc. VARIANT II TURBO Link, enables on-demand, automated diabetes testing in a random access setting.

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