Weight Loss Vaccine That Allows You to Eat All You Want is Possible, Says Study

Weight Loss Vaccine
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A recent study reveals a novel weight loss vaccine with initial results that indicate that it is possible to lose weight and still eat all that you want.

Obesity is a worldwide epidemic that thus far has failed to be stymied by dieting, exercise, weight loss pills and supplements for the majority of people actively seeking to lose weight. One novel approach to preventing weight gain and increasing weight loss is treating obesity as a disease not unlike polio that can be treated with a vaccine and allow a person to live life as usual without restrictions—in this case, eating as much as he or she wants to without the consequences of being obese.

In a recent study published in the online, open access journal titled Journal of Animal Science and Biotechnology, researcher Keith Haffer of Braasch Biotech LLC— a privately held, preclinical stage Vaccine Company that specializes in biopharmaceutical vaccine products for the human and animal healthcare market—believes that he and his associates have come upon a novel way of fighting obesity with a vaccine that increases metabolism.

Previous studies have shown that growth hormone (GH) and insulin-like growth factor 1 (IGF-1) act to raise metabolism resulting in accelerated loss of body fat. When exogenous growth hormone is given to animals as well as humans in clinical studies, the result is a positive effect toward reducing obesity.

The normal expression of GH and IGF-1 is controlled by a hormone called somatostatin that has an inhibitory effect on the expression of GH and IGF-1 in the body. Keith Haffer hypothesized that if a vaccine were created that induced the body to make antibodies that bound to the somatostatin hormone, that the somatostatin would then be prevented from inhibiting the expression of GH and IGF-1. This in turn would result in increased levels of GH and IGF-1 circulating in the body and thereby increase a person’s metabolism.

The hypothesis was put to the test with an experiment designed to determine if immunization with a somatostatin vaccine could reduce weight gain and increase weight loss in obese mice fed a high fat diet.

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In the experiment, two similar anti-somatostatin vaccines labeled “JH17” and “JH18” were separately administered to two groups of ten diet-induced obese male mice and compared to a group of ten control obese mice that received saline injections rather than the vaccinations. Vaccinations in the test mice were given at day 1 and at day 22 of the 6-week long study, throughout which all mice were continually fed a high fat diet.

What resulted was remarkable. Within four days after the initial vaccinations, the JH17 and JH18 vaccinated mice experienced a 10% weight loss that was not seen in the saline injected control mice. Due to the degree of weight loss with the initial vaccination, the test mice received a reduced vaccine dose on day 22 that resulted in an initial weight loss of 2.1% and 1.8% during the 3 days following the 2nd round of vaccinations with the modified JH 17 and JH18 vaccines respectively. The weight losses in the test mice were maintained throughout the study in spite of continuing to eat a high fat diet, whereas the control mice continued to gain weight on the high-fat diet.

Blood analysis at the end of the study revealed that the vaccinated mice possessed antibodies to somatostatin. They also determined that the overall appetite of the vaccinated mice was not affected and that the amount of food consumed by the vaccinated mice was not statistically different from the amount of food that the control mice ate during the study.

According to a press release issued by BioMed Central (the publisher of the Journal of Animal Science and Biotechnology)—"This study demonstrates the possibility of treating obesity with vaccination", Keith explained. He continued, "Although further studies are necessary to discover the long term implications of these vaccines, treatment of human obesity with vaccination would provide physicians with a drug- and surgical- free option against the weight epidemic."

Braasch Biotech LLC plans on filing their weight loss vaccine with the U.S. Food and Drug Administration next year.

Image source: Courtesy of MorgueFile

Reference: "Effects of novel vaccines on weight loss in diet-induced-obese (DIO) mice" Journal of Animal Science and Biotechnology 2012, 3:21; Published: 9 July 2012; Keith Haffer

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