Study Shows Latest Appetite Suppressant Reduces Belly Fat
A new study reports that a new appetite suppressant that can be sprinkled over your food or dissolved in your mealtime drink may work for weight loss as scientists try to find ways to change food rather than change people’s eating habits in the battle against obesity.
Researchers of this new study say that Propionate-friendly fiber consumption may offer a new weight management option for dieters who have difficulty in sticking to a diet. Proprionate is a short chain fatty acid that is believed to play an important role in appetite regulation by stimulating the release of appetite suppressing hormones that tell the brain when the body is full.
The research is based on earlier studies that have demonstrated that dietary fiber is associated with appetite suppression and weight loss. When dietary fiber is broken down in the gut by bacteria, byproducts such as the short chain fatty acid propionate from specific gut bacteria cause the release of the appetite suppressing hormones PYY and GLP-1. When mice were given fecal transplants of gut bacteria that produce significant amounts of propionate, the mice experienced reduced weight gain and had less body fat.
To determine whether propionate may have similar results in humans, researchers conducted two small clinical trials that compared the effects of eating propionate over a control dietary fiber supplement using overweight adult volunteers as test subjects.
In the first trial, 20 volunteers were given either a propionate supplement or a typical fiber supplement just before being turned loose on a buffet table and told that they could eat as much as they like. After the buffet raid, the volunteers were assessed as to how much each ate and what their levels of the appetite suppressing hormones were following the meal.
The results of the first trial showed that test subjects given the propionate supplement ate 14% less than the test subjects who ate a typical fiber supplement; and, that the propionate group also had higher levels of the appetite-suppressing hormones PYY and GLP-1 in their blood.
In the second trial, 60 overweight adult volunteers were given either a daily 10 gram dose of the propionate supplement or a daily 10 gram dose of a typical fiber supplement over a period of 24 weeks, during which they were requested not to change their usual dietary and exercise habits. Of the 60 participants, 49 completed the trial.
Comparing baseline weight and other measurements before and after the study period, the researchers found that among the remaining 25 people taking the propionate supplement, just one put on more than 3% of his or her baseline weight. This is in comparison with six of the remaining 24 who were treated with a typical fiber supplement alone and put on more than 3% of his or her baseline weight.
Furthermore, the propionate supplement group experienced visible trimming of abdominal fat tissue compared to the control group and had lower amounts of fat in their livers.
Although the trials were small and therefore not statistically significant, it does indicate the importance propionate may have on controlling weight and could be used as a supplement before meals to prevent the gain of additional yearly weight that naturally comes during middle age.
The authors of the study concluded that their data demonstrates for the first time that increasing colonic propionate prevents weight gain in overweight adult humans.
“The present results support a role specifically for colonic propionate in weight management and may provide a molecular explanation of recent data that have observed changes in the gut [range of bacteria] and associated [short chain fatty acid production] profiles in weight loss,” stated the authors in a news release.
For more about appetite suppressing supplements, here are the results of Dr. Oz's top 4 appetite suppressants compared to natural suppressants for fighting belly fat.
Reference:“Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults” Gut 10 December 2014 doi: 10.1136/gutjnl-2014-307913 Open Access Article published online.