Side Effect-Free Diet Pill Shows Promise for Losing Weight Safely
Researchers announce success for a new diet pill that is expected to be side effect-free for losing weight safely.
A news release from the Salk Institute for Biological Studies reports the development of a novel type of diet pill that tricks the body into thinking it has consumed calories and thereby induces the body to begin burning fat, prompting some to dub it as “the imaginary meal diet pill.” Based on successful results in weight loss in mice, not only is the drug―called “fexaramine”―expected to result in weight loss in humans, but be free of the typical side effects observed in other weight loss drugs.
“This pill is like an imaginary meal,” says Ronald Evans, director of Salk’s Gene Expression Laboratory and senior author of the new paper, published January 5, 2015 in Nature Medicine. “It sends out the same signals that normally happen when you eat a lot of food, so the body starts clearing out space to store it. But there are no calories and no change in appetite.
Because fexaramine remains in the intestine and is not readily absorbed into the blood stream, researchers believe that it will thereby cause fewer (if any) side effects.
How Fexaramine Works toward Weight Loss
Fexaramine’s mechanism of action is believed to an activation of the farensoid X receptor (FXR)―a protein that plays a role in how the body releases bile acids from the liver, digests food and stores fats and sugars. FXR is normally turned on at the beginning of a meal as the body prepares itself for an influx of food. This in turn changes blood sugar levels triggering the body to begin burning fat, but without the actual intake of added fat calories from a meal. Hence―the imaginary meal diet pill moniker.
Here is a video by the researchers that explains more about fexaramine:
Weight Loss and Other Study Results
Studies with obese mice demonstrated that when fed a daily fexaramine pill for five weeks that the obese mice:
• Stopped gaining weight
• Lost fat
• Developed lower blood sugar and cholesterol levels
• Experienced a rise in body temperature–a signal of increased metabolism
• Converted deposits of white fat into healthier, energy-burning beige brown fat
Next Step toward Market and Your Weight Loss
According to the Salk Institute news release the researchers are working to set up human clinical trials to test the effectiveness of fexaramine toward treating obesity and metabolic disease with the intention that the drug would be administered under a doctor’s guidance in conjunction with diet and lifestyle changes, similar to weight-loss surgeries or other obesity or diabetes drugs.
Diet Pill Resources:
For information about diet pills that are currently available, here are some recommended links to follow:
Salk News Release: "Imaginary meal" tricks the body into losing weight
“Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance” Nature Medicine (2015) doi:10.1038/nm.3760; Published online 05 January 2015; Sungsoon Fang et. al.