Important New Green Coffee Bean Weight-loss Supplement Findings
In a recent article published in the Journal of Agricultural and Food Chemistry, researchers investigated whether or not taking high doses of the active ingredient in green coffee bean weight-loss supplements that are touted as miracle weight-loss pills really live up to their claims while still consuming a high-fat diet.
For nearly two years, green coffee bean diet products consisting primarily of extracts of the green coffee bean’s active ingredient―Chlorogenic acid (CGA)―have been promoted on The Dr. Oz Show and in the news media as the new natural and easy way to lose weight. However, in spite of published reports in scientific journals attesting to the weight loss benefits of green coffee bean extract that include preventing metabolic disease syndrome, the practical reality of weight loss results among users of the supplements have been varied and may temp some users to up their doses to achieve and/or increase weight loss results.
In the study, the researchers used laboratory mice as their animal model for determining the effects of taking high doses of Chlorogenic acid on obesity and other symptoms of metabolic disease syndrome while on a high-fat diet.
For 12 weeks, male mice were divided into groups that were fed either a high-fat diet alone or a high-fat diet with CGA added. During the study, the mice were analyzed for their high-fat-diet-induced obesity, glucose intolerance, insulin resistance, fatty acid oxidation and insulin signaling.
What the researchers found was that the mice on the high-fat diet alone and the mice on the high-fat diet plus CGA, gained the same amount of weight. In other words, CGA did not live up to its touted promise of preventing obesity or causing weight loss.
However, more significantly, the researchers discovered that high doses of CGA can actually be potentially harmful. They found that the mice that were fed CGA in their high fat diet were more likely to develop disorders that lead to Type 2 diabetes by noting increased resistance to insulin in the CGA-treated mice as well as a build-up of fat in the livers of the mice fed CGA.
The authors of the study concluded that their results suggest that higher doses of CGA supplementation in a high-fat diet does not protect against features of the metabolic syndrome in diet-induced obese mice.
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Reference: “Supplementation of a High-Fat Diet with Chlorogenic Acid Is Associated with Insulin Resistance and Hepatic Lipid Accumulation in Mice” J. Agric. Food Chem., 2013, 61 (18), pp. 4371–4378 DOI: 10.1021/jf400920x; Aidilla Mubarak et al.