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Brain & Nervous System

Novel Therapeutics for ALS: Becoming reality

Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative condition that is almost always fatal; usually in three to five years after diagnosis. Most recently we have lost Steven Hawkin who was a very great scientist-he suffered from this disorder. The etiology of ALS remains unresolved and no effective treatment exists. This study looked at an area of ALS potential treatment that is understudied. Reprogramed induced pluripotent stem cells from patient cells reverse key hallmarks of cellular age. Increased recognition of cell type-specific aging paradigms underscores the importance of tipping the balance from a state of compensated dysfunction to decompensation and progression.

New Hope for Duchenne Muscular Dystrophy Patients and Their Families

hospice care

Duchenne muscular dystrophy is an inherited neuromuscular disorder primarily occurring in boys and caused by mutations in the dystrophin gene. New treatments other than the classic glucocorticoids have started phase 2 testing. This brings hope to patients and families currently dealing with Duchennes.

Promising Research for Treatment of Glioma

Human brain scan

Glioblastoma and its variants are, at present, unable to be cured. Once diagnosed the life expectancy is only 15 months or so. They can occur at any age but most are seen in people between the ages of 50 and 70. In just the past two years studies have been moved from animal trials to human trials and are showing promise. No matter what their outcomes, further research is needed.

Cracking the “How to Improve Brain Health” Code with BioPQQ

How to Improve Brain Health

With the advancement of modern science, audiences of all ages are impacted by increasing awareness about the importance of brain health. Experts expect Alzheimer’s disease to triple in the American population by 2050, and this is just one of many alarming statistics regarding the rate of cognitive decline. As people research ways to delay cognitive decline and improve brain health, there is a new supplement on the horizon that offers hope for the future of our brains called BioPQQ. This new supplement may crack the “How to Improve Brain Health” code.

Autism and Theory of Mind: Possibly Another Way to Understand Autism

Autism mind

Being able to reach a reasonable conclusion of the internal states of others is called mentalization and is critical for successful social interactions. The main components of this system are the medial prefrontal cortex and the temporal-parietal junction. These areas show similar patterns during both the performance and observations of actions. People with autism have trouble mentalizing. This is important as difficulties with this in adults with autism; this is evident in tasks involving action processing. In addition, this issue can impair the understanding of the social intentions of others and this can lead to inappropriate social decisions. These decisions then can lead to maltreatment by others. This study was done to see if there was connectivity between regions of mentalization system when inferring the social intention of others from their actions. Adults with autism are significantly impaired on tasks that involve integrating information regarding others’ intended states with the surrounding context.

Attempts to Find New Treatments and Better Understanding of Schizophrenia

Human brain

A large group of researchers have uncovered a novel mechanism of neurotransmitters is released in the brain during schizophrenia. This elevated protein was noted not only schizophrenia but also other mental illnesses. the study was the first to study the relationship between mental illness and the level of protein. This is important as schizophrenia affects nearly one in 100 American adults and remains poorly understood.

Brain size and Schizophrenia

Human brain

In the picture above, the different lobes of the brain are color coded. According to the studies found concerning brain volume and schizophrenia, there are two main areas affected. These areas are colored green and the blue lobe that borders on the green. This illustrates why it is so important for research to continue in order to help those afflicted with schizophrenia as it is a lifelong disorder.

Autophagy: Potential target for treating neurodegenerative disorders

Neurodegenerative disorders targeting

Autophagy is a dynamic cellular pathway involved in the turn over of proteins, protein complexes, and organelles through lysosomal degradation. Defects in autophagy affect the intercellular communication and subsequently contributing to neurodegeneration. The presence of abnormal autophagy activity is frequently observed in selective neuronal populations in neurodegeneration seen in diseases like ALS, Alzheimer's, Parkinson's, and Huntington's disease.

Genetic Links Found for Autism and Schizophrenia

Mental health and human brain

Since the completion of the human genome project, researchers have been discovering changes to hundreds of places in the DNA. Some of these variants have been associated with psychiatric diseases such as autism spectrum disorder and schizophrenia. Researchers have found a roadmap for the development of new generation therapy for psychiatric conditions. In the last decade, scientists have conducted genetic studies of people with a psychiatric disease, comparing results to healthy individuals to find genes that have different sequencing in those diseases. This paper helps to explain the roles of tens of thousands of sections of regulatory DNA and proteins in the brain. Once again this study is but a jumping off place for further studies (Geschwind et al, 2018). Dendritic structure (dendrite is a short branched extension of a nerve cell along which impulses received from other cells at synapses are transmitted to the cell body) is tightly coupled with synaptic function in basal conditions. Many brain disorders are associated with an aberrant regulation of F-actin and impaired signaling. These alterations likely underlie the aberrant spine morphology found in these disorders. Further studies on the mechanism of structural plasticity of dendritic spines will provide new therapeutic targets and methods for the treatment of neuropsychiatric disorders (Borovac et al, 2018).

Connection between Vitamin D deficiency and neurological conditions

Vitamin D

Dementia is a syndrome usually progressive and chronic in nature. Global incidences of dementia is increasing at a rate of one new case every three seconds with associated medical social and health care costs far exceeding the capacity of most countries. Because of the degenerative nature of the disease sufferers lose their ability to perform routine tasks, experience poor quality of life and loss of autonomy. The role of vitamin D in the etiology of cognitive impairment and dementia is plausible and has been supported substantial mechanistic and epidemiological data. As people age, they tend to spend less and less time outdoors in the sun. It is of great importance as vitamin D deficiency is a worldwide pandemic and is seen most commonly in older adults residing in northerly latitudes, particularly during winter months. Further research needs to be done to see if increasing vitamin D level will improve cognitive health (Aspell, Lawlor, O'Sullivan, 2018).

Autism Spectrum Disorder and Issues Impairing Employment

Autism mind

Autistic Spectrum Disorders are a complex pervasive neurodevelopmental condition associated with lifelong difficulties. these difficulties cross social, emotional and behavioral domains. The lastest version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) finally put all aspects of autism under one umbrella of autistic spectrum disorder. Since this happened questions have been raised if this has helped by moving toward a broader categorization of the disorder is clinically useful (Montgomery et al, 2016).

Top 10 Myths About the Opioid Epidemic, Drug Addiction, and Relapse Debunked

drug addiction myths

The opioid epidemic still rages across our nation in a tragic wildfire of destruction and death. We are talking about an overwhelmingly tragic number of American lives that are being ravaged and families whose hearts are being shattered…somebody’s parent, spouse, or child. There are many common misconceptions and myths about the opioid epidemic, addiction, and relapse in our society, and today we are going to debunk 10 of them including drug addiction myths.

Adolescence cannabis use: Risk for Schizophrenia

girl smoking cigarette

Drug addiction is a serious socioeconomic problem associated with significant mortality and morbidity. this study highlighted the complex relationship between drug-induced neuroadaptations in the brain and addictive behaviors using examples from both human studies and animal models. these neuroadaptations thought to be responsible for the transition to a persistent state of addiction. addiction is a highly integrated process complicated by differing profiles the drug themselves. this, of course, includes the use of cannabis by youngsters. it has been shown to open the adolescents up to not only addiction but mental illnesses as well (Duncan, 2012).

The Biggest Misconception Regarding Your Sleep Apnea Diagnosis

Sleep Apnea Diagnosis

A recent survey conducted by Jazz Pharmaceuticals revealed that 1/3 of patients with a sleep apnea diagnosis also suffered from a medical condition known as Excessive Daytime Sleepiness which caused them to miss out on activities and negatively impacted their quality of life on multiple levels. A common misconception regarding a sleep apnea diagnosis is that a CPAP machine is the final solution, but research shows otherwise.

Artificial Sweeteners: Helpful or Harmful

icing sugar with artificial sweeteners

Artificial sweeteners were first introduced as a tactic to combat the shortage of sugar. Lately, it has been utilized as a way to help deal with obesity but research has been found that they actually may be making the issue worse. With all the issues noted in studies of the side effects of non-caloric artificial sweeteners, it may be better for a person to stick to a more natural diet (Brown, 2018). Artificial sweeteners are low cost and having a sweetness greater than that of normal table sugar they are commonly used in the baking industry. In spite of their beneficial effects, these sweeteners have documented health issues. In some cases, long-term exposure can lead to enforcer. A careful review of the literature by consumers and health professionals is necessary in an effort to make well-informed decisions about their health (Nisa et al, 2016).

Researchers Make Progress in Treatment of Glioblastoma

Technological advances have increased tremendously our understanding of molecular characteristics and genetic drivers for a variety of brain tumors. Although targeted therapies have had a considerable impact on patients outcomes, GBM remains an exception. the identification of targetable driven mutations in GBM has opened new potential treatment options for affected patients. On the basis of these findings, the efficacy of new targeted agents is currently being investigated in clinical trials (Ippen et al, 2018).

Looking for Genetic Link to Autism

In some cases of ASD, the birth order makes no difference. It has been suggested that children who have ASD who are not first born may experience reduced access to resources because their parents' attention might be split between a child with ASD and their older sibling. In addition, the older sibling may overcompensate for a younger sibling with ASD and that may, in turn, hinder development.

Why You Should Join the Keto Coffee Craze and Reap the Health Benefits

Coffee equals energy

The ketogenic diet is taking the world by storm. The ketogenic diet ranked amongst the top of the diet and fitness Google searches of 2016. Keto coffee is receiving high praise from health gurus everywhere. If you don’t want to have more energy or shed some pounds, the keto coffee craze is not for you.

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