Lower Levels of Anti-Inflammatory Proteins May Contribute To Chronic Widespread Pain
Chronic widespread pain, a common medical condition, can be difficult to treat and is often associated with fatigue, poor sleep and depression. A connection between fibromayalgia (FM) and cytokines (proteins that act as messengers between cells) was suspected after cancer patients treated with the cytokine interleukin -2 developed FM-like symptoms. Since then, other studies have shown contradictory results. A new study published in the August 2006 issue of Arthritis & Rheumatism examined cytokine profiles in patients with chronic widespread pain and found that they had significantly lower levels of the anti-inflammatory cytokines IL-4 and IL-10.
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