Scientists Exploit Novel Route To Reverse Enlarged Hearts in Obese Mice

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Heart

Nerve growth factor makes end run around leptin, a brain hormone linked to appetite regulation

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Working on genetically engineered obese mice with seriously thickened hearts, a condition called cardiac hypertrophy, scientists at Johns Hopkins have used a nerve protection and growth factor on the heart to mimic the activity of the brain hormone leptin, dramatically reducing the size of the heart muscle.

Leptin is a protein hormone made by fat cells that signals the brain to stop eating.

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