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Variation in Gene and Age-Related Macular Degeneration

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Columbia University/University of Iowa Study Suggests Inflammation And Other Immune Responses Might Trigger Genetic Cause of Blindness in Elderly

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Age-related macular degeneration, the leading cause of blindness in the elderly, occurs when a common inherited gene variation is triggered, possibly by an infection, according to a new study led by researchers at Columbia University Medical Center and the University of Iowa, with an international research team.

The gene, known as Factor H, encodes a protein that regulates immune defense against infection caused by bacteria and viruses.