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Researchers Identify OCD Risk Gene

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Obsessive-compulsive disorder

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Scientists at the National Institutes of Health's (NIH) National Institute on Alcohol Abuse and Alcoholism (NIAAA) have identified a previously unknown gene variant that doubles an individual's risk for obsessive-compulsive disorder (OCD). The new functional variant, or allele, is a component of the serotonin transporter gene (SERT), site of action for the selective serotonin reuptake inhibitors (SSRIs) that are today's mainstay medications for OCD, other anxiety disorders, and depression.

"Improved knowledge of SERT's role in OCD raises the possibility of improved screening, treatment, and medications development for that disorder," said Ting-Kai Li, M.D., Director, National Institute on Alcohol Abuse and Alcoholism. "It also provides an important clue to the neurobiologic basis of

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