Treatment of Down Syndrome in Mice Restores Nerve Growth in Cerebellum
Researchers at Johns Hopkins restored the normal growth of specific nerve cells in the cerebellum of mouse models of Down syndrome (DS) that were stunted by this genetic condition. The cerebellum is the rear, lower part of the brain that controls signals from the muscles to coordinate balance and motor learning.
The finding is important, investigators say, because the cells rescued by this treatment represent potential targets for future therapy in human babies with Down syndrome. And it suggests that similar success for other Down syndrome-related disruptions of brain growth, such as occurs in the hippocampus, could lead to additional treatments - perhaps prenatally - that