Moisturization, Exfoliation Study Development Is Positive

Armen Hareyan's picture
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Skin Moisturization And Exfoliation

Dermatrends has demonstrated positive results in a human study to evaluate its proprietary Hydroxide Releasing Agent technology on human skin for moisturization and exfoliation (removal of dead skin cells).

The study validated that Dermatrends' HRA technology can be used to improve the efficacy of commonly used moisturizing and exfoliating agents. This milestone study opens the door for Dermatrends to move beyond drug delivery and to participate in the dynamic cosmetic personal skin care market.

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In the seven day study, Dermatrends' formulations demonstrated positive results in the 16 parameters monitored by the clinical study firm. The methods used in evaluations of 16 parameters included visual examination by a trained laboratory examiner, quantitative measurements by skin science instrumentation, and self-assessments by the study subjects. The Dermatrends' formulations compared favorably throughout the seven day period against the untreated (negative) control and against two controls that included popular major brand OTC products sold in the anti-aging skin care category.

The study, conducted by Hill Top Research, used a sample coded (identity blinded) method to compare the effect of Dermatrends formulations as well as two commercial branded products. Comparisons were made from both Dermatrends formulations and the control commercial products against initial baseline values and an untreated negative control site. Study subjects ranged in age from 21 to 65 years.

Dermatrends' formulation showed a statistically significant change from the baseline for both moisturization and exfoliation. Exfoliation is a central purpose of anti-aging cosmetic products.

Measurements from scientific instrumentation included Corneometer readings of skin capacitance to gauge skin moisture levels, D-SQUAME measurements to assess skin turnover time (dead skin surface cells replaced by younger cells from deeper layers of the skin) and Transepidermal Water Loss (TEWL) measurements to monitor skin barrier function. Study subjects also provided self assessments in a laboratory setting and were able to identify changes in their skin's smoothness, moisturization and softness after use of all test articles. The measurements of Dermatrends' formulations showed improvements from baseline values and from the negative control throughout the entire seven day period. The branded control products did not achieve the same positive results at the end of 24 hours or throughout the study.

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