Nicotinic receptors may be important targets for treatment of multiple addictions
For years, scientists have known that some people are biologically more susceptible to drug addiction than others, but they have only been able to speculate why.
In the August 15, 2007 issue of the Journal of Neuroscience, researchers at the University of Chicago report on a study that may help answer this question.
They discovered that rats most likely to self-administer addictive drugs had a particular receptor in the brain that is more responsive than the same receptor in rats least likely to self-administer addictive drugs.
This receptor, known as the nicotinic acetylcholine receptor (nAChR), increases excitability within in the brain