HIV-Infected Infants Respond Poorly To Childhood Vaccination
It is known that HIV-infected children who do not receive appropriate antiretroviral drugs experience immune depression, and may become susceptible to infectious diseases that would otherwise be prevented by childhood immunization.
It is therefore important to find out to what extent HIV-infected children are able to generate adequate levels of antibodies following routine childhood immunizations.
A paper published online this week in PLoS ONE describes the results of a cross-sectional study carried out amongst 18-36 month-old children born to HIV-infected mothers and living in Central Africa.
The study suggested that immuno-suppressed HIV-infected children have a low persistence of antibodies to the vaccines of the Expanded Program on Immunization (EPI, WHO). The study was conducted in Cameroon and the Central African Republic by pediatricians, epidemiologists, bacteriologists and virologists, and coordinated by the Institut Pasteur (Paris, France) through its International Network, particularly the institutes based at the Pasteur Center in Yaound