Acute Leukemia Sign May Signal Need for Different Therapy

Armen Hareyan's picture
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Leukemia Treatment

A type of chromosome change that was thought to predict a good response to treatment in patients with acute myeloid leukemia (AML) might actually signal the need for a different therapy to achieve the best outcome. The findings from this new study may alert doctors that they need to change their treatment approach for certain AML patients.

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The study compared AML patients whose cancer cells showed chromosome changes known as the 8;21 translocation with patients whose cancer cells showed chromosome damage known as inversion 16.

Currently, AML patients with either the 8;21 translocation or the inversion 16 abnormalities receive the same therapy. They also tend to experience complete remission and have a better overall survival than do patients with most other subtypes of AML.

But this study found that when the two groups of patients are compared with each other

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