Viventia Biotech Reports Positive Data From Cancer Trial
Viventia Biotech intends to explore strategic alternatives to further advance and realize value from its pipeline of therapeutic antibodies, its antibody discovery platform and its antibody manufacturing capabilities. The Company will consider potential strategic opportunities including, but not limited to, the sale or merger of the Company with another entity, and has retained HSBC to act as advisors in this process.
The Company also provided an update on the clinical development programs for Proxinium (Phase 3), Vicinium (Phase 2) and VB6-845 (Phase 1). Proxinium is undergoing a global pivotal Phase 3 trial (the 'TARGET' trial) in approximately 300 patients with advanced head and neck cancer. Viventia recently completed an interim efficacy assessment on the study's primary endpoint of median survival. These preliminary results demonstrated a clear survival advantage in the Proxinium arm.
"We have successfully advanced three antibody programs into clinical trials, and are about twelve months from expected final efficacy data for our pivotal Phase 3 TARGET trial of Proxinium. We believe that our recently performed interim efficacy analysis of survival data from TARGET strongly supports the future prospects for this drug. In addition to our clinical programs, we have generated a broad pipeline from our antibody discovery platform, which has yielded a number of compelling novel targets, including several that have expression profiles consistent with cancer stem cells, an exciting new area of cancer research," said Dr. Nick Glover, President and CEO of Viventia Biotech. "We believe it is important to explore all options to ensure adequate resources are available for the advancement of our products through to commercialization and to further recognize the value of our proprietary discovery platform."
Viventia's late-stage pipeline consists of Armed Antibodies, a novel class of anti-cancer therapeutics that are designed to be safer and more beneficial for cancer patients. These products are fusion proteins comprised of human/humanized monoclonal antibody fragments specific to cancer cell markers, conjugated to highly potent cytotoxic proteins.
Viventia's three lead products target EpCAM, which has recently also been identified as a cancer stem cell marker and is one of the most frequently over-expressed cancer antigens known. A growing body of evidence implicates a functional role for EpCAM in diverse cellular processes such as signaling, cell migration, proliferation, and differentiation. Viventia's clinical portfolio represents one of the most significant anti-EpCAM programs in active development.