Researchers Discover Gene Switched Off In Cancer Can Be Turned On
A gene implicated in the development of cancer cells can be switched on using drugs.
The finding could lead to a new class of targeted cancer therapies with potential to benefit many different cancer types.
Popular new drugs such as Herceptin and Gleevec more effectively treat cancer by targeting genetic mutations that express themselves in large amounts, causing cancer to develop. But cancers also arise because genes that control growth are turned off. While researchers can use these turned-off genes to identify or monitor cancer, currently no treatments actually target these genes.
U-M researchers found that a gene called Brahma, or BRM, is silent