Potent Anti-Tumor Activity Of Antibody-Drug Conjugates In Cancer Animal Models

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Medarex, Inc. presented preclinical data demonstrating potent anti-tumor activity from two separate studies exploring the efficacy and safety in animal models of anti-CD19 and anti-CD70 antibody-drug conjugates.

CD19 and CD70 are both attractive targets for an antibody-drug conjugate approach to cancer therapy. They are expressed on cancer cells with limited normal patterns of expression and are rapidly internalized when bound to antibody. Data from the studies were presented at the American Association for Cancer Research (AACR) annual meeting, April 14-18, 2007, in Los Angeles, CA.

Efficacy study of anti-CD19 antibody drug conjugates in Raji tumor xenograft and systemic model (Abstract #4104)

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CD19 is expressed on B cell cancers, including non-Hodgkin's lymphoma, chronic lymphocytic leukemia and acute lymphocytic leukemia. Single dose treatments of a fully human anti-CD19 antibody drug conjugate demonstrated in vivo anti-tumor efficacy leading to the regression of established subcutaneous tumors and systemic tumors in leukemia xenograft models. Anti-CD19 antibody- drug conjugate was well-tolerated and without toxicity in the animal models.

Single, low dose treatment of lymphoma and renal cancer xenografts with human anti-CD70 antibody toxin conjugates, results in long term cures (Abstract #4112)

CD70 is highly expressed in multiple tumor types, including many lymphomas and clear cell renal cancer. Single, low dose treatments of a fully human anti-CD70 antibody drug conjugate demonstrated in vivo anti-tumor efficacy in both preclinical lymphoma and renal cancer xenograft animal models. The anti- CD70 antibody drug conjugate demonstrated a high specificity for its target, a wide therapeutic window of activity, and a favorable toxicity and safety profiles in larger animals at dose levels which are in excess of an efficacious dose determined in the xenograft models.

"Antibody-drug conjugates exploit the specificity of antibodies and the potency of cytotoxic agents to destroy cancer cells," said Nils Lonberg, PhD, Senior Vice President and Science Director at Medarex. "We believe that the anti-tumor activity from these preclinical antibody-drug conjugate studies is quite compelling, and we look forward to fully exploring the safety and therapeutic activity and application of these programs in future clinical trials."

Medarex is a biopharmaceutical company focused on the discovery, development and potential commercialization of fully human antibody-based therapeutics to treat life-threatening and debilitating diseases, including cancer, inflammation, autoimmune disorders and infectious diseases.

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