One Wwox Isn't Enough To Protect Against Cancer

Armen Hareyan's picture
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A new study shows that the loss of even one of the two copies of a particular tumor-suppressor gene greatly increases the risk that lung cancer will develop in experimental animals.

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The study examined the Wwox gene, a suspected tumor-suppressor gene, and showed that even when mice have one working copy of the gene, they nonetheless develop five times more lung tumors than do mice with both copies of the gene. Tumor-suppressor genes normally keep damaged cells from becoming cancerous.

The findings were published March 6 in the Proceedings of the National Academy of Sciences by investigators at the Ohio State University Comprehensive Cancer Center.

"Classic tumor-suppressor genes don

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