For healthcare workers, there has been a vaccine for Hepatitis B for some time now. T-cell immunity plays a vital role in pathogen infections. MicroRNA are small, single-stranded non-coding RNAs that regulate T-cell immunity by targeting key factors, signaling and proteins and cytokines associated with T-cell activation, differentiation, and function. This study of specific immune responses can provide new therapeutic opportunities against various infectious diseases.
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Obesity remains an epidemic in the US as well as worldwide. Little has been studied and understood about the epigenetic basis of obesity in adolescents. There has been found an association between the level of DNA methylation in obesity-related genes and BMI percentile. In the last decade, a novel mechanism of epigenetic regulation of gene expression has been studied. Although there is increased awareness of lifestyle and environmental factors associated with obesity, there remain major gaps that exist in understanding the contribution of epigenetics.
Glioblastoma and its variants are, at present, unable to be cured. Once diagnosed the life expectancy is only 15 months or so. They can occur at any age but most are seen in people between the ages of 50 and 70. In just the past two years studies have been moved from animal trials to human trials and are showing promise. No matter what their outcomes, further research is needed.
Stem cell therapy is the future of regenerative medicine, but will stem cell therapy also define the future of healthcare in the United States? In this article, we will explore the benefits of stem cell therapy along with the impact this regenerative revolution will have on healthcare.
Data on HPV in women have prompted researchers to elicit more options and better outcomes. And while there is a vaccine available for HPV few people take advantage of it for various reasons. HPV has been linked to cervical cancer-seems pretty straightforward. Take the vaccination to decrease the chance of cervical cancer.
Metastatic renal cell carcinomas still are the most lethal in the US. In 2015 alone there were 14,080 deaths attributed to it. Removal of the involved kidney continues to be the mainstay treatment for localized disease. Even with all our advancements in treatment, it continues to have a poor prognosis. Chemotherapy is considered a standard therapy for patients with some renal cell variants. The role in treating clear cell renal cell carcinoma is poorly defined. What exactly causes this resistance is currently undefined. Ideally, doctors should be able to characterize tumors according to DNA. In reality, this method has been largely limited by varying gene expression signatures. For years development of treatment has been largely unsuccessful. Better understanding disease biology and treatment resistance patterns have led to emerging therapies with a better understanding in pathogensis and mechanisms of treatment resistance there are hope treatments will continue to expand (Tsao et al, 2017).
Ovarian cancer is the most lethal of all gynecological malignancies. This is in part because of the symptomology of the disease until it is at a late stage. Because of the five-year survival rate is only 45% while the actual cause of epithelial cancer of the ovary or fallopian tube is not known, studies have found about 15% are shown to be connected with the inherited genetic factors such as BRCA 1&2 mutations. The standard line of defense is surgery and treatment with platinum-based chemotherapy. Unfortunately, recurrence is high with the recurring disease resistant to further chemotherapy. Recently olaparib has shown some promise in treating BRCA 1&2 mutations that have led to ovarian cancer. It is thought this occurs along the DNA repair pathways that make the cancer cells sensitive to olaparib. The validity of the study's data was confirmed by repeated tests across different fields (Fleury et al. 2017).
It is estimated that there are over 338,000 new cases of pancreatic cancer worldwide. in 2012, 331,000 people died from pancreatic cancer. Because the therapies for other cancers have been showing more advancement the researchers feel that pancreatic cancer is liable to become the second leading cause of cancer death worldwide. Patients with advanced pancreatic cancer, to survive more than a year is only slightly improved due to use of systemic chemotherapy and the combining use of other chemotherapies already available. This trial that adjuvant therapy using gemcitabine is the standard of care based on similar survival to and less toxicity than paired with 5-fluorouracil/folinic acid in patients with resected pancreatic cancer (meaning they have had all or part of the tumor removed surgically). In addition, other trials have shown better survival and tumor response with gemcitabine and capecitabine as opposed to gemcitabine used alone in advanced or metastatic pancreatic cancer. The outcome of the study found promise with the use of gemcitabine and capecitabine resulting in an increase in survival times to between two and five years without relapse (Neoptolemos et al, 2017)
In high-income countries, cancer remains the commonest cause of disease-related death in adolescent and young adults despite survival improvements. With more than one million new diagnoses of cancer in adolescents and young adults annually worldwide, and their number of life-years affected by cancer being greatest of all ages, the global burden of cancer in adolescents and young adults exceeds all other ages. In low- and middle-income countries, where the great majority of the worlds adolescents and young adults reside the needs of those with cancer have been identified and demand attention. Unique to this age group, the psychosocial challenges they face are the utmost across life's spectrum (Brunet et al, 2018)
Cancer is a tragic plague that wracks our world with suffering. Most Americans have been impacted by this horrific disease in a personal or professional way. Hodgkin Lymphoma is a blood cancer that invades the lives of thousands every year, but the tragic fact about this type of cancer is that it usually targets young adults. Hodgkin Lymphoma is not in the spotlight often due in part to its rarity and the fact that treatment for newly diagnosed patients didn’t change for over 40 years. Fortunately, Adcetris offers new hope for Hodgkin Lymphoma treatment.
Melanoma is a malignant tumor derived from melanocytes (the cells that give skin its color) and is the deadliest form of skin cancer risk factors for melanoma include family history, sex, age, skin pigmentation, sunburn susceptibility, tanning ability, nevus (moles) count and freckling and psychological health. In addition, socioeconomic features, occupation, access to health, and preventive measures, latitude have been demonstrated to impact the morbidity of melanoma (Helgadottir et al, 2018). Shared success and progress of the pigment cell research community in the understanding of cellular and immunological homeostasis of pigment cells but also clinical challenges and hurdles in the treatment of melanoma and dermatological disorders continue to drive further research activities. Investigators in the pigment cell research community have diverse but complementary backgrounds. The cross-disciplinary nature of the field is unique, unified around the passion of understanding normal pigmentation and benign or malignant pigmentary diseases (Filipp et al, 2018).
We hear a lot about skin cancer, lung cancer, prostate cancer, and even pancreatic cancer, but oral cancer? Not so much. The Oral Cancer Foundation estimated that nearly 50,000 Americans would be diagnosed with oral cancer in 2017. Oral cancer has a significant mortality rate, as slightly more than half of the people diagnosed with the disease will be alive in five years.
Kidney cancer is amongst the 10 most common cancers known to mankind according to the American Cancer Society, and the disease is often fatal as the percentage of Americans diagnosed with kidney cancer continues to climb higher each year. Fortunately, the future is looking brighter with the introduction of new kidney cancer treatments and continuing research by brilliant scientists.
A woman’s chance of developing breast cancer during her lifetime is about 1 in 8. In men, the chance is 1 in 1,000. That’s a big difference, so big, in fact, that many people don’t even realize that men can have breast cancer and that they can die from it just like women can.
For many years, people have attempted to find the cure for cancer. There are many common treatments that people go through in order to get rid of cancer. While they sometimes are effective, unfortunately, they come with serious side effects.
As part of her dissertation, Cornelia Rosschger from Salzburg has designed a molecule to be used in the fight against cancer. The molecule causes cancer cells to not divide so quickly. The helical molecule is a representation of a small element of the Id proteins, but is not an exact copy. It has the ability to recognize and capture Id proteins, thus weakening their biological function in the cancer cell.
A 10% increase in processed food consumption would increase the risk of developing cancer by 12%, according to a new French study that followed nearly 105,000 participants over 8 years.
According to a study carried out on mice published today in the British publication NatureAn, an international team of researchers has programmed nanorobots to search for, and destroy tumors by cutting off their blood supply. The entire process occurs within 24 hours and impressive results were observed in a melanoma mouse model.
Nutrition is an important factor in boosting and maintaining immune system health. Eating a diet rich in fruits and vegetables has been shown in studies to be a preventative of cancer. This is why it's shocking that the most healing of all non-cancer foods - asparagus, has come under attack.
New animal research published in the journal, Nature, suggests that food can either fuel or inhibit the spread of cancer. This is due to the amino acid composition of foods because certain cancers appear to thrive on specific amino acids.
Today the World Health Organization (WHO) released this picture discussing ways to reduce your cancer risk. There are lots of good points there, but the HPV vaccination as a way to reduce cancer risk created a big controversy on its Facebook page.
I don't know if it's the alcohol itself or the extra ingredients that go in today's alcohol drinks, but the World Health Organization (WHO) today announced that drinking alcohol can increase the risk of at least 7 types of cancer and limiting alcohol intake is one way to reduce your cancer risk. Apparently it's the ethanol in alcoholic drinks.
The 13-year-old boy has spent the last 8 months believing he is going to die from brain cancer because his parents allegedly told people that their child has terminal brain cancer in a phony, yet successful attempt to get donations to help with the cost of his medical expenses.
Maintaining a healthy diet, exercising regularly and avoiding smoking, makes it possible to prevent up to a third of the most common cancers, says On World Day Against Cancer, The Ministry of Health recalls preventive measures Doctor Fernando Arenillas from the Oncology Service of the San Martin de Parana Hospital in Argentina.
We know that cancer eats -- it is self-sustaining and lives off of what you put into your body. Sugar has long been blamed for feeding cancer, while animal products, particularly meat, have flown under the radar. This misinformation has thrown fruit under the bus as a healthful option and has prevented many cancer patients from healing.
Medical science says that invasive procedures such as biopsies and early screenings are the answer to cancer progression, but this is not prevention. While there are many types of cancer screening tests, cancer prevention may be possible years ahead of its development with one simple blood test.
I have been hearing a lot of buzz about dry fasting lately and even hearing that people are kicking cancer with it. Of course, you hear all kinds of things. Personally, I am intrigued, but how true can claims like these possibly be?
President Franklin Delano Roosevelt’s famous quote: “The only thing we have to fear is fear itself” is proving to be true beyond the Great Depression to the modern world today. The New England Journal of Medicine released a study in April of 2012 called “Suicide and Cardiovascular Death After a Cancer Diagnosis”. The study’s results were a saddening testimony to the fact that fear can be fatal.
Doctor Vaagn Andikyan of Armenian decent, attributes the successful treatment and good prognosis to the delivery of high quality, compassionate care, and team-based collaboration by cancer care experts at the Danbury Hospital.
I ran across this statistic for the first time a few days ago and found it quite puzzling. Why would such a large percentage of doctors refuse a treatment that they would recommend to others?