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Trojan Horse Helps Deliver New Male Contraceptive Compound To Testis

Armen Hareyan's picture

Male Contraceptive Pill

The development of effective, reversible, and safe contraceptives for men has lagged far behind the availability of methods for women, largely because scientists lack sufficient knowledge about male reproductive physiology. Improving this state of affairs has been a key aim of scientists at the Population Council's Center for Biomedical Research. In one of the Council's labs, biochemist and cell biologist C. Yan Cheng and his colleagues have found a way to target a new drug, known as Adjudin, to the testis in rats. This method induces reversible infertility without interfering with hormones secreted by the hypothalamus, pituitary gland, and testis.

"The hormones of the hypothalamus pituitary-testicular axis regulate male sex drive and maintain the health of other targets, including bone, muscle mass, and the sex organs. Male contraceptives that bypass this hormonal system would be welcome because they would be likely to leave these organs and libido intact," says R