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Disease and Condition
Autophagy is a dynamic cellular pathway involved in the turn over of proteins, protein complexes, and organelles through lysosomal degradation. Defects in autophagy affect the intercellular communication and subsequently contributing to neurodegeneration. The presence of abnormal autophagy activity is frequently observed in selective neuronal populations in neurodegeneration seen in diseases like ALS, Alzheimer's, Parkinson's, and Huntington's disease.
Many studies have been conducted about finding lasting pain relief from osteoarthritis-the number one reason for joint pain; especially in older adults. Medication doesn't always work and they often come with unwanted side effects. It is time to investigate alternative ways to treat this joint pain.
Idiopathic pulmonary fibrosis is a chronic disease. The clinical management and treatment of this fatal disease are challenging for various reasons. And although antifibrotic therapies exist, doctors are still unable to tell which patient will benefit from individual treatments.
Collection of dietary intake data can be challenging with the potential of errors in validity and reliability. Nutritional assessments are important to determine dietary strategies. There are limitations with these methodologies as not all nutrients have reliable markers of status.
Since the completion of the human genome project, researchers have been discovering changes to hundreds of places in the DNA. Some of these variants have been associated with psychiatric diseases such as autism spectrum disorder and schizophrenia. Researchers have found a roadmap for the development of new generation therapy for psychiatric conditions. In the last decade, scientists have conducted genetic studies of people with a psychiatric disease, comparing results to healthy individuals to find genes that have different sequencing in those diseases. This paper helps to explain the roles of tens of thousands of sections of regulatory DNA and proteins in the brain. Once again this study is but a jumping off place for further studies (Geschwind et al, 2018). Dendritic structure (dendrite is a short branched extension of a nerve cell along which impulses received from other cells at synapses are transmitted to the cell body) is tightly coupled with synaptic function in basal conditions. Many brain disorders are associated with an aberrant regulation of F-actin and impaired signaling. These alterations likely underlie the aberrant spine morphology found in these disorders. Further studies on the mechanism of structural plasticity of dendritic spines will provide new therapeutic targets and methods for the treatment of neuropsychiatric disorders (Borovac et al, 2018).
Venomous animals are widely spread all over the globe. Several terrestrial vertebrates (reptiles, birds, insects, and mammals) are also venomous. Major arthropods (scorpions, bees, and wasps) have multicellular glands attached to the stinging apparatus. Bee venom obtained from stepwise fractionation has been reported to contain peptides (Prasasty et al, 2018). It has been known for many years that venom of insects like wasps and bees have compounds that can fight bacteria. Along with that, however, for many humans, these same insect venoms cause toxic reactions so without some kind of refinement was needed. researchers at MIT took the toxin from a South American wasp and created variants of the peptide that are potents against bacterial while nontoxic to human cells. As part of their immune defenses, many organisms produce peptides that can kill bacteria. To help fight the emergence of antibiotic-resistant bacteria, many scientists have been trying to adapt these peptides as potential drugs. The study found that the peptide from the venom is believed to kill microbes by disrupting the cell membranes on bacteria (Torres et al, 2018)
Dementia is a syndrome usually progressive and chronic in nature. Global incidences of dementia is increasing at a rate of one new case every three seconds with associated medical social and health care costs far exceeding the capacity of most countries. Because of the degenerative nature of the disease sufferers lose their ability to perform routine tasks, experience poor quality of life and loss of autonomy. The role of vitamin D in the etiology of cognitive impairment and dementia is plausible and has been supported substantial mechanistic and epidemiological data. As people age, they tend to spend less and less time outdoors in the sun. It is of great importance as vitamin D deficiency is a worldwide pandemic and is seen most commonly in older adults residing in northerly latitudes, particularly during winter months. Further research needs to be done to see if increasing vitamin D level will improve cognitive health (Aspell, Lawlor, O'Sullivan, 2018).
Parkinson's disease is a prevalent disorder that affects approximately 40-1000 people per 100,000 with increased occurrence in older individuals. It is characterized by progressive neurodegeneration that can manifest in early stages as mild cognitive impairment and moderate motor dysfunction, rigidity and tremor. As the disease progresses, the severity escalates as well. This then includes falls, difficulty swallowing and neuropsychiatric complications including psychosis. this psychosis can occur in up to 75% of cases of this disease (Kitten et al, 2018).
This study found that a daily hydroxyurea pill may finally bring some relief for young children living with sickle cell anemia. This could be a big game changer for resource-challenged sub-Saharan Africa where the disease is prevalent and health care is suboptimal (Ware et al, 2018). Few studies had been done where the burden is greatest. The study published in the New England Journal of Medicine found treatment was feasible and safe in children living in the area of Africa most affected. It proved to reduce vaso-occlusive events, infections, malaria, transfusions, and death. These results illustrate a need for more access to treatments. In the US and Europe early identification of children with sickle cell by means of neonatal screening. This allows these children to be given simple effective, and lifesaving interventions (Tshilolo et al, 2018).
Enterovirus D68 has historically been a rare sporadic disease-causing occasional small outbreaks and a generally mild infection. Mostly these were respiratory in nature like a runny nose, cough and muscle aches. Recently the illness and caused more severe disease and has been focusing more in children. The first large-scale outbreak of EVD68 was reported in the US and Canada. From August 2014 to January 2015 a total of 1153 cases in 49 states with 10.4% cases of acute flaccid myelitis in the US and five cases of EVD68 in Canada. Several clusters of acute flaccid myelitis have been noted in recent years associated with EVD68 and EVA71. further investigation into the relationship is important because of the severity of acute flaccid myelitis and because there currently is no treatment for acute flaccid myelitis related to EVD68 or vaccines to prevent it (Dyda et al, 2018).
Influenza activity in the US began to increase in early November 2017 and rose sharply from December through February 3, 2018. From October 2017 to January 1, 2018, the weekly percentage of deaths from pneumonia and flu ranged from 5.8% to 10.1% and has exceeded the epidemic threshold for five consecutive weeks. During seasons with increased severity of influenza, antiviral medications are an important adjunct to vaccinations. Additional study is needed to see if this year's virus will mutate and develop resistance to the four antiviral medications available. In addition to seeing just how effective the current influenza vaccination will be in controlling influenza transmission (Budd et al, 2018).
Optimal pharmacological treatment for COPD patients reduces symptoms, reduces the frequency and severity of exacerbations, improve health status and increases exercise tolerance. Unfortunately, despite frequent changes in COPD classification systems and the emergence of new inhaled therapies recommended from evidence-based guidelines, poor adherence to treatment due to the cost of medication and lack of availability of medications create a gap in real-life prescribing patterns (Cases et al, 2018).
In childhood, recurrent abdominal pain in children is a common complaint. The reason behind it is what needs further investigation as it affects approximately 10% of children. It is a descriptive umbrella term and accounts for many visits to primary, secondary, and emergency care facilities. It is now referred to as one of four functional abdominal pain disorders; dyspepsia, abdominal migraine, irritable, bowel syndrome and functional abdominal pain. One thing most parents need to keep in mind is when was the last time the child had a bowel movement. This author pointed out that there are many conditions of abdominal pain that require no intervention. Routine use of pharmacotherapy for functional abdominal pain is not well supported or suggested. In fact, in some cases, medications can mask the signs and symptoms needed to monitor for a more serious condition. It is felt some doctors will prescribe probiotics just so the parents will feel something is being done in a condition that needs no treatment at the time and will be sell limiting (Edwards, 2018).
Autistic Spectrum Disorders are a complex pervasive neurodevelopmental condition associated with lifelong difficulties. these difficulties cross social, emotional and behavioral domains. The lastest version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) finally put all aspects of autism under one umbrella of autistic spectrum disorder. Since this happened questions have been raised if this has helped by moving toward a broader categorization of the disorder is clinically useful (Montgomery et al, 2016).
Metastatic renal cell carcinomas still are the most lethal in the US. In 2015 alone there were 14,080 deaths attributed to it. Removal of the involved kidney continues to be the mainstay treatment for localized disease. Even with all our advancements in treatment, it continues to have a poor prognosis. Chemotherapy is considered a standard therapy for patients with some renal cell variants. The role in treating clear cell renal cell carcinoma is poorly defined. What exactly causes this resistance is currently undefined. Ideally, doctors should be able to characterize tumors according to DNA. In reality, this method has been largely limited by varying gene expression signatures. For years development of treatment has been largely unsuccessful. Better understanding disease biology and treatment resistance patterns have led to emerging therapies with a better understanding in pathogensis and mechanisms of treatment resistance there are hope treatments will continue to expand (Tsao et al, 2017).
Ovarian cancer is the most lethal of all gynecological malignancies. This is in part because of the symptomology of the disease until it is at a late stage. Because of the five-year survival rate is only 45% while the actual cause of epithelial cancer of the ovary or fallopian tube is not known, studies have found about 15% are shown to be connected with the inherited genetic factors such as BRCA 1&2 mutations. The standard line of defense is surgery and treatment with platinum-based chemotherapy. Unfortunately, recurrence is high with the recurring disease resistant to further chemotherapy. Recently olaparib has shown some promise in treating BRCA 1&2 mutations that have led to ovarian cancer. It is thought this occurs along the DNA repair pathways that make the cancer cells sensitive to olaparib. The validity of the study's data was confirmed by repeated tests across different fields (Fleury et al. 2017).
It is estimated that there are over 338,000 new cases of pancreatic cancer worldwide. in 2012, 331,000 people died from pancreatic cancer. Because the therapies for other cancers have been showing more advancement the researchers feel that pancreatic cancer is liable to become the second leading cause of cancer death worldwide. Patients with advanced pancreatic cancer, to survive more than a year is only slightly improved due to use of systemic chemotherapy and the combining use of other chemotherapies already available. This trial that adjuvant therapy using gemcitabine is the standard of care based on similar survival to and less toxicity than paired with 5-fluorouracil/folinic acid in patients with resected pancreatic cancer (meaning they have had all or part of the tumor removed surgically). In addition, other trials have shown better survival and tumor response with gemcitabine and capecitabine as opposed to gemcitabine used alone in advanced or metastatic pancreatic cancer. The outcome of the study found promise with the use of gemcitabine and capecitabine resulting in an increase in survival times to between two and five years without relapse (Neoptolemos et al, 2017)
Financial concerns are often cited by doctors as a barrier to administering routinely recommended vaccines to adults. Survey respondents answered questions on payment and profit for various public and private payer types. Over half of respondents reported losing money vaccinating adult Medicaid beneficiaries. Few respondents reported negotiation with manufacturers or insurance plans on vaccine purchase prices or payments for vaccinations. Claim denial is a major reason many adults don't inquire about vaccinations or seek them out with their doctors (Lindley et al, 2018; Potter et al, 2018).
Artificial sweeteners were first introduced as a tactic to combat the shortage of sugar. Lately, it has been utilized as a way to help deal with obesity but research has been found that they actually may be making the issue worse. With all the issues noted in studies of the side effects of non-caloric artificial sweeteners, it may be better for a person to stick to a more natural diet (Brown, 2018). Artificial sweeteners are low cost and having a sweetness greater than that of normal table sugar they are commonly used in the baking industry. In spite of their beneficial effects, these sweeteners have documented health issues. In some cases, long-term exposure can lead to enforcer. A careful review of the literature by consumers and health professionals is necessary in an effort to make well-informed decisions about their health (Nisa et al, 2016).
Prescription drug monitoring programs are central to federal and state policy responses to address prescription abuse. They are state run electronic database s of prescription medications. Unfortunately, even with these programs in place, there is evidence of limited benefit. Finds of the study suggest drug monitoring programs have a limited impact on individual level opioid utilization. They agree that further studies are needed (Moyo, 2017).
Many women suffer from depression while going through menopause. antidepressants- SSRI or SNRIs (selective serotonin reuptake inhibitors or serotonin and noradrenaline reuptake inhibitors) are commonly used as the first line response. Unfortunately the treatment has shown only small improvements with troublesome side effect.
It has been reported by the GAO-government accountability office, that prices on drugs doubled between 2000 and 2008. The rise was attributed to industry consolidations and price hikes by third-party providers who repackage drugs. And while generics can lower the prices after branded patents expire, branded manufacturers lose approximately 80% of their market share. It should also be noted, that in the US it takes an average of 12 years for a drug to pass through all the trials as it moves from test tube to patent. And the patent protection starts when the molecule is first registered with the patent office. So once it is released for sale the companies often only have 8 years on average to recover the costs of research and productions of the medication and turn a profit (Dooney & Hunter, 2014).
Outdoor air pollution is a major contribution to air pollution. This study found high-efficiency particulate air filters (HEPA) used in the home significantly reduces fine particulate matter in the air compared to non-HEPA air filters. In this study, researchers monitored air quality for 12 weeks in homes enrolled patients who have respiratory issues. HEPA filters were found to reduce fine particulate matter by 55% and outside pollution coming inside reduced by 23%. Fine particulate matter is defined as small airborne particles often found in areas with heavy air pollution. When inhaled they can lead to respiratory difficulty, heart attacks, or exacerbate symptoms of COPD or asthma. The study was partially done in response to patients who had asked their doctor what they could do to protect their lungs during poor air quality days (Carlton, 2018).
Technological advances have increased tremendously our understanding of molecular characteristics and genetic drivers for a variety of brain tumors. Although targeted therapies have had a considerable impact on patients outcomes, GBM remains an exception. the identification of targetable driven mutations in GBM has opened new potential treatment options for affected patients. On the basis of these findings, the efficacy of new targeted agents is currently being investigated in clinical trials (Ippen et al, 2018).
Lyme disease is caused by bacteria of the genus Borrelia transmitted by the bite of a tick of the genus Ixodes. the is transmitted by ticks infected with various diseases in both Europe and North America. Both places are affected by a similar species of genus of bacteria. It is a spirochete belonging to B. burgdorferi sensu stricto are primarily found in America while in Europe it is Ixodes ricinus. the time needed to transmit the disease is usually within 12 hours of attachment. This is why it is so important to remove ticks as soon as found and to treat our pets with flea and tick preventative (Sertour, 2018).
Healthcare-associated infections (HAI) can be reduced by up to 55% by systematically implementing evidence-based infection prevention and control strategies. HAI come at a considerable expense to patient and families but also cost the US healthcare system an estimated $9.8 billion each year. This study found healthcare institutions have a responsibility to improve the quality of patient care and reduced infection rates by effectively implementing customized multifaceted strategies and improved patient outcomes (Schreiber et al, 2018).
Important factors that may contribute to both etiology and treatment and are increasingly being explored as targets for alternative treatment development. Diet and nutrition are important factors of disease. Many dietary compounds are transformed by the microbiome that can change the etiology of illness. Thus, the use of targeted probiotics has shown promise in the treatment of illnesses in humans.
As more Americans age, there is an increasing number of older adults who are still not able to access the care they need for an acceptable quality of life.
Rabies is a virus that has a fatal outcome if it is not treated in humans. In the US, most states have laws that make it mandatory to have cats, dogs, and ferrets to be vaccinated for rabies each year. In some cases, they can use the three-year vaccine but the pet needs to receive a booster if they come in contact with a rabid animal.
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