Altering Bugs In The Gut Could Tackle Non-Alcoholic Fatty Liver Disease

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Non-Alcoholic Fatty Liver Disease

Altering the makeup of bugs in the gut could be a way of tackling insulin resistance and related problems such as non-alcoholic fatty liver disease, according to new research published this week.

The study also has implications for the treatment of associated conditions such as type 2 diabetes, obesity and heart disease.

The research shows that the type of microbes found in the guts of mice with a certain genetic makeup causes them to be pre-disposed to insulin resistance and non-alcoholic fatty liver disease (NAFLD). On a high fat diet, these microbes transform the nutrient choline, found in food and essential for metabolising fat, into methylamines.

Scientists believe that these methylamines, which can only be produced by the microbes in the gut, lead to insulin resistance. In addition, because choline is needed to transport fat out of the liver, altering choline metabolism leads to fat accumulating in the liver and NAFLD.


The researchers are hopeful that their results in mice mean that they could intervene to change the makeup of gut microbes in people, to prevent their microbes from changing choline into methylamine. This would greatly reduce a person's chances of becoming insulin resistant, developing NAFLD or suffering from associated problems.

The research is published this week in the Proceedings of the National Academy of Sciences by researchers from Imperial College London and the Wellcome Trust Centre for Human Genetics, University of Oxford.

Professor Jeremy Nicholson, senior author of the paper from Imperial College London, said: "It has been known for some time that a person's genetic makeup can make them pre-disposed to insulin resistance and associated conditions. Finding out how this pre-disposition is linked to microbes in the gut offers us the prospect of tackling major health problems in people by intervening to change the makeup of these microbes. This is much more feasible than altering a person's genetic makeup."

The researchers measured the plasma and urine of two genetic strains of mice using nuclear magnetic resonance spectroscopy and computer modelling. One strain had a genetic predisposition to insulin resistance and NAFLD whilst the other strain did not.

The authors conclude their study provides more evidence that complex metabolic diseases are the product of the human and bacterial genomes as well as diet and lifestyle.

About non-alcoholic fatty liver disease is a fatty inflammation of the liver related to insulin resistance that in its most extreme form can cause cirrhosis. There is currently no standard treatment for the disease and patients are usually encouraged to try weight loss or insulin sensitisers to reduce its effects. It is estimated to affect between 10-27% of the world's population.