Immune-System Cells May Promote Chronic Infections in Cystic Fibrosis
Cells sent to fight infections in the lungs of cystic fibrosis patients actually enhance the development of permanent bacterial infections, according to researchers at National Jewish Medical and Research Center. Infections with the bacteria Pseudomonas are a major cause of sickness and death in cystic fibrosis patients. The findings, published in the June issue of Infection and Immunity, suggest new treatment strategies for patients with cystic fibrosis.
"Pseudomonas can use the remnants of dead white blood cells to develop a protective biofilm, which helps the bacteria establish a permanent infection," said National Jewish pulmonologist Jerry Nick, M.D., senior author on the paper. "So, ironically, the very cells sent to fight infection may contribute to our inability to eradicate the Pseudomonas infection in cystic fibrosis patients."
Cystic fibrosis (CF) is a genetic disorder affecting about 30,000 people in the United States, and is the most common genetic disorder among Caucasian people. People with