Reflective Confocal Microscopy - Feasible Alternative In Diagnosis Of Actinic Keratoses

Armen Hareyan's picture

Actinic Keratoses

Study found reflective confocal microscopy may be a feasible alternative to skin biopsy in the diagnosis of actinic keratoses against normal skin, as well as in the detection of subclinical forms of this disease.

The article, titled "Actinic keratoses: non-invasive diagnosis of field cancerisation," reports that the study's preliminary findings suggest that reflective confocal microscopy (RCM) "may be a useful non-invasive tool fordetecting actinic keratoses (AKs)" and that RCM "may be a feasible alternative to clinical diagnosis alone and could aid in the differentiation of AKs against normal skin, as well as in the detection of subclinical disease."


"In the context of 'field cancerisation'," the paper states, "repeated and multiple biopsies may not always be considered a practical approach. Therefore, evidence suggests that RCM may be a promising tool for the non- invasive evaluation, diagnosis and monitoring of AKs."

"The VivaScope 1500 potentially provides an alternative to routine skin biopsy in many clinical situations," said Jay Eastman, chairman and CEO of Lucid, Inc. "With the publication of this new study, the potential effectiveness of Vivascope technology has been shown for the detection of actinic keratoses, a precursor to squamous cell carcinoma.

"Lucid VivaScope imagers are used in a number of leading US and European research hospitals. Publication of this new study is expected to further accelerate the growing acceptance of VivaScope technology by clinical institutions and private practices alike," Eastman said.

The objective of the study was to evaluate the RCM-morphology of clinically diagnosed AKs in the study population and to correlate the findings with routine histopathology. Evaluation consisted of clinical examination, RCM and routine histology. RCM evaluation parameters included parakeratosis, architectural disarray and keratinocyte pleomorphism.