Global Early Warning Can Prevent Future Pandemics

Armen Hareyan's picture

Professor of epidemiology says, that HIV pandemic can be prevented and he's working to prevent the next one.

Writing in the May 17 edition of the journal Nature, Wolfe and UCLA colleagues Jared Diamond and Dr. Claire Panosian Dunavan identify five evolutionary stages in a pathogen's journey from exclusive transmission among animals to exclusive transmission among humans. They also re-examine the origins and characteristics of 25 of the most important diseases in human history.

The extensive review provides evidence supporting the development of the first global monitoring system for tracking the transmission of disease from animals to humans. Such a system would help scientists catalog the diversity of microbial agents, characterize animal pathogens that might threaten humans in the future, and perhaps detect and control emergence of a disease in humans before it can spread.

"We can not just sit around and wait for the next HIV pandemic," Wolfe said. "We need to move away from the old-fashioned fire brigade approach to disease control and move toward disease forecasting."

Infectious diseases springing from wild primate populations regularly infect human populations of hunters and gatherers, a cycle that presumably has endured for millions of years. A handful of pathogens evolve into specialized diseases transmitted only through human to human contact --- sometimes, as in the case of HIV, with devastating results.


In 1999, Wolfe began field work in the jungles of Cameroon to track "viral chatter," or the regular transmission of diseases from animals to people, usually without further spread among humans. By monitoring the habits and the blood pathologies of bushmeat hunters and their kills, Wolfe and his team have identified at least three previously unknown retroviruses from the same family as HIV, as well as promoted safe practices for handling animals and animal carcasses.

"The Cameroon project demonstrated that it's possible to collect information on viral transmission under very difficult circumstances from these highly exposed people," Wolfe said.

With Cameroon as a prototype and a $2.5 million National Institutes of Health Pioneer Award as seed money, Wolfe has gone on to create a network of virus-discovery projects that monitor hunters, butchers, and wildlife trade and zoo workers in some of the world's most remote viral hotspots. The network of a dozen sites in China, the Democratic Republic of Congo, Malaysia, Laos, Madagascar and Paraguay include source locations for such emerging diseases as SARS, avian flu, Nipah, Ebola and monkeypox.

In addition to the NIH award, funding included a Fogarty International Research Scientist Development Award, a W.W. Smith Foundation award and a grant from the National Geographic Society.

Wolfe and his colleagues begin by identifying five intermediate stages through which a pathogen exclusively infecting animals must travel before exclusively infecting humans. The research team identifies no inevitable progression of microbes from Stage 1 to Stage 5 and notes that many microbes remain stuck at a specific stage. The journey is arduous, and pathogens rarely climb through all five stages: