Ovarian cancer is the most lethal of all gynecological malignancies. This is in part because of the symptomology of the disease until it is at a late stage. Because of the five-year survival rate is only 45% while the actual cause of epithelial cancer of the ovary or fallopian tube is not known, studies have found about 15% are shown to be connected with the inherited genetic factors such as BRCA 1&2 mutations. The standard line of defense is surgery and treatment with platinum-based chemotherapy. Unfortunately, recurrence is high with the recurring disease resistant to further chemotherapy. Recently olaparib has shown some promise in treating BRCA 1&2 mutations that have led to ovarian cancer. It is thought this occurs along the DNA repair pathways that make the cancer cells sensitive to olaparib. The validity of the study's data was confirmed by repeated tests across different fields (Fleury et al. 2017).
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Disease and Condition
It is estimated that there are over 338,000 new cases of pancreatic cancer worldwide. in 2012, 331,000 people died from pancreatic cancer. Because the therapies for other cancers have been showing more advancement the researchers feel that pancreatic cancer is liable to become the second leading cause of cancer death worldwide. Patients with advanced pancreatic cancer, to survive more than a year is only slightly improved due to use of systemic chemotherapy and the combining use of other chemotherapies already available. This trial that adjuvant therapy using gemcitabine is the standard of care based on similar survival to and less toxicity than paired with 5-fluorouracil/folinic acid in patients with resected pancreatic cancer (meaning they have had all or part of the tumor removed surgically). In addition, other trials have shown better survival and tumor response with gemcitabine and capecitabine as opposed to gemcitabine used alone in advanced or metastatic pancreatic cancer. The outcome of the study found promise with the use of gemcitabine and capecitabine resulting in an increase in survival times to between two and five years without relapse (Neoptolemos et al, 2017)
Financial concerns are often cited by doctors as a barrier to administering routinely recommended vaccines to adults. Survey respondents answered questions on payment and profit for various public and private payer types. Over half of respondents reported losing money vaccinating adult Medicaid beneficiaries. Few respondents reported negotiation with manufacturers or insurance plans on vaccine purchase prices or payments for vaccinations. Claim denial is a major reason many adults don't inquire about vaccinations or seek them out with their doctors (Lindley et al, 2018; Potter et al, 2018).
Artificial sweeteners were first introduced as a tactic to combat the shortage of sugar. Lately, it has been utilized as a way to help deal with obesity but research has been found that they actually may be making the issue worse. With all the issues noted in studies of the side effects of non-caloric artificial sweeteners, it may be better for a person to stick to a more natural diet (Brown, 2018). Artificial sweeteners are low cost and having a sweetness greater than that of normal table sugar they are commonly used in the baking industry. In spite of their beneficial effects, these sweeteners have documented health issues. In some cases, long-term exposure can lead to enforcer. A careful review of the literature by consumers and health professionals is necessary in an effort to make well-informed decisions about their health (Nisa et al, 2016).
Prescription drug monitoring programs are central to federal and state policy responses to address prescription abuse. They are state run electronic database s of prescription medications. Unfortunately, even with these programs in place, there is evidence of limited benefit. Finds of the study suggest drug monitoring programs have a limited impact on individual level opioid utilization. They agree that further studies are needed (Moyo, 2017).
Many women suffer from depression while going through menopause. antidepressants- SSRI or SNRIs (selective serotonin reuptake inhibitors or serotonin and noradrenaline reuptake inhibitors) are commonly used as the first line response. Unfortunately the treatment has shown only small improvements with troublesome side effect.
It has been reported by the GAO-government accountability office, that prices on drugs doubled between 2000 and 2008. The rise was attributed to industry consolidations and price hikes by third-party providers who repackage drugs. And while generics can lower the prices after branded patents expire, branded manufacturers lose approximately 80% of their market share. It should also be noted, that in the US it takes an average of 12 years for a drug to pass through all the trials as it moves from test tube to patent. And the patent protection starts when the molecule is first registered with the patent office. So once it is released for sale the companies often only have 8 years on average to recover the costs of research and productions of the medication and turn a profit (Dooney & Hunter, 2014).
Outdoor air pollution is a major contribution to air pollution. This study found high-efficiency particulate air filters (HEPA) used in the home significantly reduces fine particulate matter in the air compared to non-HEPA air filters. In this study, researchers monitored air quality for 12 weeks in homes enrolled patients who have respiratory issues. HEPA filters were found to reduce fine particulate matter by 55% and outside pollution coming inside reduced by 23%. Fine particulate matter is defined as small airborne particles often found in areas with heavy air pollution. When inhaled they can lead to respiratory difficulty, heart attacks, or exacerbate symptoms of COPD or asthma. The study was partially done in response to patients who had asked their doctor what they could do to protect their lungs during poor air quality days (Carlton, 2018).
Technological advances have increased tremendously our understanding of molecular characteristics and genetic drivers for a variety of brain tumors. Although targeted therapies have had a considerable impact on patients outcomes, GBM remains an exception. the identification of targetable driven mutations in GBM has opened new potential treatment options for affected patients. On the basis of these findings, the efficacy of new targeted agents is currently being investigated in clinical trials (Ippen et al, 2018).
Lyme disease is caused by bacteria of the genus Borrelia transmitted by the bite of a tick of the genus Ixodes. the is transmitted by ticks infected with various diseases in both Europe and North America. Both places are affected by a similar species of genus of bacteria. It is a spirochete belonging to B. burgdorferi sensu stricto are primarily found in America while in Europe it is Ixodes ricinus. the time needed to transmit the disease is usually within 12 hours of attachment. This is why it is so important to remove ticks as soon as found and to treat our pets with flea and tick preventative (Sertour, 2018).
Healthcare-associated infections (HAI) can be reduced by up to 55% by systematically implementing evidence-based infection prevention and control strategies. HAI come at a considerable expense to patient and families but also cost the US healthcare system an estimated $9.8 billion each year. This study found healthcare institutions have a responsibility to improve the quality of patient care and reduced infection rates by effectively implementing customized multifaceted strategies and improved patient outcomes (Schreiber et al, 2018).
Important factors that may contribute to both etiology and treatment and are increasingly being explored as targets for alternative treatment development. Diet and nutrition are important factors of disease. Many dietary compounds are transformed by the microbiome that can change the etiology of illness. Thus, the use of targeted probiotics has shown promise in the treatment of illnesses in humans.
As more Americans age, there is an increasing number of older adults who are still not able to access the care they need for an acceptable quality of life.
Rabies is a virus that has a fatal outcome if it is not treated in humans. In the US, most states have laws that make it mandatory to have cats, dogs, and ferrets to be vaccinated for rabies each year. In some cases, they can use the three-year vaccine but the pet needs to receive a booster if they come in contact with a rabid animal.
Ever since the implementation of electronic health records and the restraints of the Affordable Care Act, doctors have been leaving the workforce in increasing numbers. Many doctors have said it is because of with the electronic records they are always waiting for someone to put the information in the system, creating sometimes life-threatening delays in care. In addition, there has been a decrease in the numbers of young adults entering medical schools. This combination creates the shortage of manpower and the greater chance of burnout.
Tuberculosis continues to be a major healthcare problem even in this modern day of multiple medications and treatments. With growing difficulty concerning drug resistance, new drugs and repurposing of old standbys are needed more than ever.
Recently, WHO (World Health Organization) recommended the use of rotavirus vaccinations worldwide. The widespread use of these vaccines has the potential to prevent about two million deaths over the next decade. Even countries like Mexico are suggesting the use of rotavirus vaccine to have a substantial reduction of mortality of those affected.
Genetically manipulated medicine or crops are not the evil substances many have been led to believe. Farmers and animal breeders have been manipulating their crops and stock for years, This is an aspect of medicine that is not just necessary but vital to the treatments of famine and pestilences
Testing by using already approved medications are being used to aid in treatments for fatal diseases like HIV-1 and Ebola
As Summer ramps up, here in the South we are inundated with creepy crawlers that bite, sting and just plain annoy us. But one really stands out as a serious danger. The dreaded TICK. Their favorite hiding places are behind ears, in skin folds and in hair just to name a few.
Parkinson’s disease does not seem as important as curing cancer or studying stem cells uses. However, as prevalence grows, perhaps, the money to research will follow. A very large sampling is projecting double the cases of Parkinson's Disease by 2030. It will be interesting to see if projections are accurate considering very little is known about the cause, and much less how to treat successfully.
It is Porphyria Awareness Week (April 21-28th). Acute hepatic porphyrias (AHPs) is a family of rare genetic diseases characterized by potentially life-threatening attacks and debilitating symptoms. AHPs mostly affects women between the ages of 20-30. AHPs patients worldwide unite this week, raising powerful voices in an effort to turn the tide of this devastating disease.
Jennifer Jones looks incredulously around her. She does understand what is going on; she seems to be in a trance. Lying on a bed at the Mayo Clinic in Rochester, Minnesota, surrounded by machines that keep her balanced and with wires going in and out of her body, she will experience something new. And she is nervous. For the first time, she can breathe on her own after a lung transplant surgery.
The United States Food and Drug Administration (FDA) approved a vagus nerve stimulator for the treatment of migraines in adults, which is called gammaCore. The portable device is placed on the vagus nerve in the neck, releasing a slight electrical stimulation to the afferent nerve fibers. gammaCore relieves migraine pain from the outside.
Social insects like bees and ants can help us develop new drugs against antibiotic-resistant bacteria. This is due to the fact that they have developed alternative strategies to defend themselves against the higher exposure to pathogens associated with social life.
Experts share flu season is likely to be severe, making it important to get your flu shot, especially for those age 65 and above. EmaxHealth asked Dr. Adam Welch, Associate Professor at the Bill Gatton College of Pharmacy at East Tennessee State University and Gina Venditti MPAS, PA-C, Board of Trustees, Physician Assistant (PA) Foundation why it is so important for older adults to get an annual flu vaccine.
Anyone with a disability has likely suffered through questions that are - so to speak - truly insufferable. Some people are upfront about their disability and willing to share; while others may not have any visible signs. One should never assume. Here is a list of seven stupid and inappropriate things that people with disabilities have been asked.
Thyroid disease, whether it is hypothyroidism, Hashimoto's, or Graves, affects patients in two contrasting types. I have been both types, and I want to empower you through my own healing journey of Hashimoto's Thyroiditis to find the courage and permission to heal yourself.