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Acid suppression between two OTC heartburn treatments

Armen Hareyan's picture

Heartburn treatment

In a new study, researchers have directly compared the early therapeutic response of drugs from widely-used classes of heartburn medications, omeprazole magnesium, a proton pump inhibitor (PPI) and famotidine, a histamine-2 receptor antagonist (H2RAs), in an over-the-counter (OTC) setting. In contrast to general consensus, suggesting first day superiority of H2RAs, the results show similar acid suppression on the first day of dosing between these drugs as reported today in Alimentary Pharmacology & Therapeutics.

Researchers also report evidence that with daily use, the body develops a rapid onset of tolerance to even a low dose H2RAs such as Pepcid AC