Novel Method Enables Genomic Screening Of Blood Vessels From Patient Tissue
Genomic Screening Of Blood Vessels
Scientists have developed a new method of capturing a complete genome-wide screening of blood vessel cells in their actual disease state, advancing the potential for genetic research on the tissue responsible for delivering nourishment that can accelerate the growth of both a cancer tumor or wound healing.
The method is not just a bonus for translational research, but also has made it possible to determine that genes long associated only with cancer are also expressed in chronic wounds.
The team of scientists, based at Ohio State University Medical Center, is using laser capture microdissection to pluck blood vessels, or if need be a single cell, from human wound tissue as part of a major research initiative looking for mechanisms underlying chronic wounds.
They published a description of the research method in the Proceedings of the National Academy of Sciences scheduled for online publication this week and print publication on Sept. 4.