COX Inhibitors May Weaken Protective Qualities Of Estrogen Hormone Therapy
Estrogen Hormone Therapy
Researchers found that COX inhibitors such as traditional nonsteroidal anti-inflammatory drugs may undermine any purported protection against heart disease in participants taking estrogen therapy.
Premenopausal women are less susceptible to heart attack and stroke than are males of the same age group, an advantage that is lost after menopause. However, why this happens physiologically is unclear. Despite the cardiovascular advantage of premenopausal women, it has been difficult to identify a cardioprotective effect of taking estrogen in postmenopausal women. The Penn research group recently found in mice that estrogen acts via COX-2