Stem Cell Transplantation Is Beneficial Treatment of Type 1 Diabetes
Type 1 Diabetes Treatment
A therapy that includes stem cell transplantation induced extended insulin independence in patients with type 1 diabetes mellitus, according to a preliminary study in the April 11 issue of JAMA.
Type 1 diabetes mellitus (DM) results from a cell-mediated autoimmune attack against pancreatic beta cells. At the time of clinical diagnosis, approximately 60 percent to 80 percent of the beta-cell mass has been destroyed, according to background information in the article. Beta-cell preservation has been shown to be an important target in the management of type 1 diabetes mellitus and in the prevention of its related complications.
Julio C. Voltarelli, M.D., Ph.D., of the University of Sгo Paulo, Ribeirгo Preto, Brazil, and colleagues conducted a study to examine the effect of high-dose immunosuppression followed by autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) to preserve beta-cell function in 15 newly diagnosed patients with type 1 diabetes mellitus. AHST, which uses a patient