Nano-Fiber Gel Delivers High Concentrations Of Clinically Approved Drugs
Researchers from Brigham and Women's Hospital (BWH) and City College of New York have developed a new self- assembling hydrogel drug delivery system that is biocompatible, efficient at drug release, and easy to tailor. The findings, which are now available online at Science Direct, will be published in the November 25 issue of Biomaterials.
These new structures can deliver clinically approved drugs in high concentrations without requiring carriers for the drug or generating toxic components, a problem with hydrogel systems until now.
"This strategy could serve as the platform technology for developing drug-based delivery gels that can release drugs such as anti-inflammatory agents on demand in response to inflammation, for example," said Jeffrey Karp, PhD, a researcher in the Department of Medicine at BWH.
"Converting known, clinically-practiced drugs into amphiphilic molecules which can undergo self-assembly is the key development in our present research; this may eliminate the need for an external carrier for delivering drugs" says Praveen Kumar Vemula, PhD, research fellow in the Department of Medicine at BWH.
The self-assembling nano-fiber gel is developed from drug-based hydrogels and can release drugs on demand, through enzyme triggered gel degradation.