Common OTC Drug Could Pose Serious Risk For Some
Solomon acknowledges the study's limitations. For one, the subjects were overwhelmingly frail, elderly patients. For another, researchers had no information on aspirin use, smoking history, body mass index, or other potential confounders. For still another, possible effects of drug dosage differences were not considered. Despite these limitations, the results have potential clinical relevance. “Our findings suggest that rofecoxib and ibuprofen are the only agents consistently associated with an increased risk for CVD events among specific patient subgroups,” Dr. Solomon notes. “The fact that we did not observe a similar concentration in risk among subgroups of patients using many of the other agents may be of even greater relevance. These results should bolster physicians’ and patients’ confidence that most Cox 2s and nonselective NSAIDs are not associated with an elevated risk of CVD events in many patient subgroups using typical doses.”
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