Ovarian cancer is the most lethal of all gynecological malignancies. This is in part because of the symptomology of the disease until it is at a late stage. Because of the five-year survival rate is only 45% while the actual cause of epithelial cancer of the ovary or fallopian tube is not known, studies have found about 15% are shown to be connected with the inherited genetic factors such as BRCA 1&2 mutations. The standard line of defense is surgery and treatment with platinum-based chemotherapy. Unfortunately, recurrence is high with the recurring disease resistant to further chemotherapy. Recently olaparib has shown some promise in treating BRCA 1&2 mutations that have led to ovarian cancer. It is thought this occurs along the DNA repair pathways that make the cancer cells sensitive to olaparib. The validity of the study's data was confirmed by repeated tests across different fields (Fleury et al. 2017).

Do "celebrity" weight loss stories inspire you? They do not inspire me. Your stories inspire me more. What about you? By the way, I wrote the word celebrity in quotation marks because for me there is nothing to celebrate about most people who attempt to influence our lives through the screen.

Many people have shown an incredible transformation of losing lots of weight following the keto diet. Does it work for everyone? Here are the pros an cont of the Ketogenic diet shared by people who are trying to lose weight.

I was always a healthy weight growing up and into my young 20s. Then, suddenly I suffered from mental health problems and decided to go onto antidepressants. While on antidepressants I gained a whopping extra 75 lbs and became very large and unhealthy. This made me even more depressed. After about a year of having all this extra weight, I decided enough was enough and wanted to try to lose the weight so I came of the medication and got serious about diet and exercise. Within one year and I was able to lose 69 lbs, but I am now at a loss of 74 lbs. Not only have I lost most of the weight, but I am much fitter than I ever was before. It has been very difficult to lose the weight, but it was the best choice I could have done as much I am happier than I have been in a few years.

Relapsing multiple sclerosis is a disease that forever changes someone’s life. It robs them of independence, mobility, and dignity, but Bryan Bickell, a retired pro ice hockey player, is serving as an inspiration to many as an advocate with a relapsing multiple sclerosis diagnosis. Fortunately, he has found ways to thrive in his life in spite of his diagnosis, and his inspirational positivity and fighting spirit shine brightly as he shares how you can overcome your multiple sclerosis diagnosis too.

In high-income countries, cancer remains the commonest cause of disease-related death in adolescent and young adults despite survival improvements. With more than one million new diagnoses of cancer in adolescents and young adults annually worldwide, and their number of life-years affected by cancer being greatest of all ages, the global burden of cancer in adolescents and young adults exceeds all other ages. In low- and middle-income countries, where the great majority of the worlds adolescents and young adults reside the needs of those with cancer have been identified and demand attention. Unique to this age group, the psychosocial challenges they face are the utmost across life's spectrum (Brunet et al, 2018)

Pedestrian accident fatalities are unfortunately on the rise. According to statistics from the National Highway Traffic Safety Administration (NHTSA), a pedestrian was killed every 1.5 hours in traffic crashes in 2016. Here are the top 10 pedestrian safety tips that you can implement as a pedestrian to minimize the risk of an accident. Fortunately, pedestrian accident attorneys are available to help you fight your battles should the need arise!

Cancer is a tragic plague that wracks our world with suffering. Most Americans have been impacted by this horrific disease in a personal or professional way. Hodgkin Lymphoma is a blood cancer that invades the lives of thousands every year, but the tragic fact about this type of cancer is that it usually targets young adults. Hodgkin Lymphoma is not in the spotlight often due in part to its rarity and the fact that treatment for newly diagnosed patients didn’t change for over 40 years. Fortunately, Adcetris offers new hope for Hodgkin Lymphoma treatment.

Drug addiction is a serious socioeconomic problem associated with significant mortality and morbidity. this study highlighted the complex relationship between drug-induced neuroadaptations in the brain and addictive behaviors using examples from both human studies and animal models. these neuroadaptations thought to be responsible for the transition to a persistent state of addiction. addiction is a highly integrated process complicated by differing profiles the drug themselves. this, of course, includes the use of cannabis by youngsters. it has been shown to open the adolescents up to not only addiction but mental illnesses as well (Duncan, 2012).

Artificial sweeteners were first introduced as a tactic to combat the shortage of sugar. Lately, it has been utilized as a way to help deal with obesity but research has been found that they actually may be making the issue worse. With all the issues noted in studies of the side effects of non-caloric artificial sweeteners, it may be better for a person to stick to a more natural diet (Brown, 2018). Artificial sweeteners are low cost and having a sweetness greater than that of normal table sugar they are commonly used in the baking industry. In spite of their beneficial effects, these sweeteners have documented health issues. In some cases, long-term exposure can lead to enforcer. A careful review of the literature by consumers and health professionals is necessary in an effort to make well-informed decisions about their health (Nisa et al, 2016).

The online world can be a dangerous environment especially if we are not aware of its danger. it has become a powerful weapon in the hands of criminals and the technology developments have created an unlimited market for them. Unfortunately, without geographical limits, human trafficking can develop at ease in different, new forms. this makes it harder for perpetrators to be identified and prosecuted. The forms of exploration are more and more diverse and recruitment methods are also subtle and intelligent. Up to now, traffickers use brutal force to recruit their victims. Now this force has changed to manipulation and persuasive tactics advanced marketing and management strategies with superior informatics. The criminals constantly update their methods and so should we. We need to start incorporating the changes in the online world and use them as a basis to protect ourselves and our families. We are the solution if you suspect trafficking don't turn your head get involved (Humelnicu, 2017).

Prescription drug monitoring programs are central to federal and state policy responses to address prescription abuse. They are state run electronic database s of prescription medications. Unfortunately, even with these programs in place, there is evidence of limited benefit. Finds of the study suggest drug monitoring programs have a limited impact on individual level opioid utilization. They agree that further studies are needed (Moyo, 2017).

It has been reported by the GAO-government accountability office, that prices on drugs doubled between 2000 and 2008. The rise was attributed to industry consolidations and price hikes by third-party providers who repackage drugs. And while generics can lower the prices after branded patents expire, branded manufacturers lose approximately 80% of their market share. It should also be noted, that in the US it takes an average of 12 years for a drug to pass through all the trials as it moves from test tube to patent. And the patent protection starts when the molecule is first registered with the patent office. So once it is released for sale the companies often only have 8 years on average to recover the costs of research and productions of the medication and turn a profit (Dooney & Hunter, 2014).

Outdoor air pollution is a major contribution to air pollution. This study found high-efficiency particulate air filters (HEPA) used in the home significantly reduces fine particulate matter in the air compared to non-HEPA air filters. In this study, researchers monitored air quality for 12 weeks in homes enrolled patients who have respiratory issues. HEPA filters were found to reduce fine particulate matter by 55% and outside pollution coming inside reduced by 23%. Fine particulate matter is defined as small airborne particles often found in areas with heavy air pollution. When inhaled they can lead to respiratory difficulty, heart attacks, or exacerbate symptoms of COPD or asthma. The study was partially done in response to patients who had asked their doctor what they could do to protect their lungs during poor air quality days (Carlton, 2018).

Every three minutes a child is rushed into a U.S. emergency room for treatment due to a toy-related injury according to research. The toy safety checklist and other resources in this article will enable parents to minimize the risk of accidents for their children based on the latest research available.