Metastatic renal cell carcinomas still are the most lethal in the US. In 2015 alone there were 14,080 deaths attributed to it. Removal of the involved kidney continues to be the mainstay treatment for localized disease. Even with all our advancements in treatment, it continues to have a poor prognosis. Chemotherapy is considered a standard therapy for patients with some renal cell variants. The role in treating clear cell renal cell carcinoma is poorly defined. What exactly causes this resistance is currently undefined. Ideally, doctors should be able to characterize tumors according to DNA. In reality, this method has been largely limited by varying gene expression signatures. For years development of treatment has been largely unsuccessful. Better understanding disease biology and treatment resistance patterns have led to emerging therapies with a better understanding in pathogensis and mechanisms of treatment resistance there are hope treatments will continue to expand (Tsao et al, 2017).

Danielle Smiddy says her biggest obstacle to losing weight was her mind. She is from Jacksonville, Fl and was interviewed by eMaxHealth sharing her amazing weight loss success and how she did. She says you have to change your mind to change your body. I agree with her. This is true for fighting not against the passion of obesity, but against any passion that plagues human life.

Families and societies have faced cycles of deadly diseases, including pandemics, for centuries with profound effects on the perceptions and realities of unseen threats. Since the 16th century, influenza pandemics have occurred at intervals ranging from 10 to 50 years. In the 20th and 21st centuries, three outbreaks of pandemic flu happened. In 1918 it was Spanish Flu with 20% to 40% of worldwide population ill and estimated 50 million people died. In 1957 an influenza virus originated in East Asia that killed between one and two million. Then in 1968, a similar flu virus originated in Hong Kong that resulted in between one and four million deaths. More recently, in the spring of 2009, spreading fast in Mexico and US, the world was rocked with another health crisis; H1N1 (Swine Flu). This study proved that there is limited benefit from flu vaccination given each year but it is better than no help at all (Aylesworth-Spink, 2017).

There are many ways you can motivate yourself to lose weight, eat healthily and lead a good lifestyle. It's important to fight against the passion of obesity and overeating. Here are 17 quotes from people who lose weight about their motivations.

It is estimated that there are over 338,000 new cases of pancreatic cancer worldwide. in 2012, 331,000 people died from pancreatic cancer. Because the therapies for other cancers have been showing more advancement the researchers feel that pancreatic cancer is liable to become the second leading cause of cancer death worldwide. Patients with advanced pancreatic cancer, to survive more than a year is only slightly improved due to use of systemic chemotherapy and the combining use of other chemotherapies already available. This trial that adjuvant therapy using gemcitabine is the standard of care based on similar survival to and less toxicity than paired with 5-fluorouracil/folinic acid in patients with resected pancreatic cancer (meaning they have had all or part of the tumor removed surgically). In addition, other trials have shown better survival and tumor response with gemcitabine and capecitabine as opposed to gemcitabine used alone in advanced or metastatic pancreatic cancer. The outcome of the study found promise with the use of gemcitabine and capecitabine resulting in an increase in survival times to between two and five years without relapse (Neoptolemos et al, 2017)

The opioid epidemic still rages across our nation in a tragic wildfire of destruction and death. We are talking about an overwhelmingly tragic number of American lives that are being ravaged and families whose hearts are being shattered…somebody’s parent, spouse, or child. There are many common misconceptions and myths about the opioid epidemic, addiction, and relapse in our society, and today we are going to debunk 10 of them including drug addiction myths.

There are nearly 10 million Americans living with a severe mental health condition according to the National Alliance on Mental Illness (NAMI). This shocking statistic reveals that mental illness is even more common than you may have suspected. In this article, we will take a look at tips from experts on how to find the best online counseling available to suit your individual needs.

Obstructive sleep apnea is associated with increased cardiovascular morbidity and mortality. This study reviewed the effects of oral appliance therapy on a broad spectrum of cardiovascular outcomes. The literature search was performed up to December 2016. The resulting data showed significant reductions in daytime systolic and diastolic blood pressure compared to baseline with no significant reductions in heart rate. The study identified both continuous positive airway pressure (CPAP) and oral airway treatment (OAT). may lead to a reduction in long-term cardiovascular morbidity and mortality in obstructive sleep apnea (OSA) patients. The study is necessary to better address their question (de Vries et al, 2017).

Financial concerns are often cited by doctors as a barrier to administering routinely recommended vaccines to adults. Survey respondents answered questions on payment and profit for various public and private payer types. Over half of respondents reported losing money vaccinating adult Medicaid beneficiaries. Few respondents reported negotiation with manufacturers or insurance plans on vaccine purchase prices or payments for vaccinations. Claim denial is a major reason many adults don't inquire about vaccinations or seek them out with their doctors (Lindley et al, 2018; Potter et al, 2018).

A recent survey conducted by Jazz Pharmaceuticals revealed that 1/3 of patients with a sleep apnea diagnosis also suffered from a medical condition known as Excessive Daytime Sleepiness which caused them to miss out on activities and negatively impacted their quality of life on multiple levels. A common misconception regarding a sleep apnea diagnosis is that a CPAP machine is the final solution, but research shows otherwise.

Melanoma is a malignant tumor derived from melanocytes (the cells that give skin its color) and is the deadliest form of skin cancer risk factors for melanoma include family history, sex, age, skin pigmentation, sunburn susceptibility, tanning ability, nevus (moles) count and freckling and psychological health. In addition, socioeconomic features, occupation, access to health, and preventive measures, latitude have been demonstrated to impact the morbidity of melanoma (Helgadottir et al, 2018). Shared success and progress of the pigment cell research community in the understanding of cellular and immunological homeostasis of pigment cells but also clinical challenges and hurdles in the treatment of melanoma and dermatological disorders continue to drive further research activities. Investigators in the pigment cell research community have diverse but complementary backgrounds. The cross-disciplinary nature of the field is unique, unified around the passion of understanding normal pigmentation and benign or malignant pigmentary diseases (Filipp et al, 2018).

Prescription drug monitoring programs are central to federal and state policy responses to address prescription abuse. They are state run electronic database used to track prescriptions and dispensing of prescribed medications. Unfortunately, even these programs in place there is evidence of limited benefit. This study found that drug monitoring programs have a limited impact on individual level opioid utilization among Medicare beneficiaries. they agree that further studies are needed (Moyo, 2017).

Many women suffer from depression while going through menopause. antidepressants- SSRI or SNRIs (selective serotonin reuptake inhibitors or serotonin and noradrenaline reuptake inhibitors) are commonly used as the first line response. Unfortunately the treatment has shown only small improvements with troublesome side effect.

Hurricane Harvey was catastrophic causing over 80 deaths and numerous injuries. Hurricane Irma then struck the FL Everglades with many people spending days in ten feet of mud and toxic stormwater. Power outages caused great concern as gas portable generators were used leading to concern of carbon monoxide. Warnings were not well followed with a family of six found drowned in their car. Flood warnings and the use of gas-powered generators are both a growing concern with these summer storms bringing more and more rain (Smith, 2018). three powerful and devastating hurricanes resulted in the deaths of hundreds of people. Power outages led to deaths from carbon monoxide poisonings that could have been prevented if people just followed the advice given by officials (Issa, 2017).

GNC or gender non-conformity has become a real issue in our schools today. A study conducted of 6082 high school students said GNC was associated with feeling sad and hopeless as well as suicidal. This leads to an increase in peer harassment and violence as well as increase exposure to child abuse. this exposure also has led to an increase in substance abuse as well as an increase experience of mental distress (Lowry et al, 2018).