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Cracking the “How to Improve Brain Health” Code with BioPQQ

How to Improve Brain Health

With the advancement of modern science, audiences of all ages are impacted by increasing awareness about the importance of brain health. Experts expect Alzheimer’s disease to triple in the American population by 2050, and this is just one of many alarming statistics regarding the rate of cognitive decline. As people research ways to delay cognitive decline and improve brain health, there is a new supplement on the horizon that offers hope for the future of our brains called BioPQQ. This new supplement may crack the “How to Improve Brain Health” code.


What is BioPQQ?

BioPQQ is a scientifically researched, nutritional ingredient commonly found in plants and meats that may improve brain health and act to protect the brain from cognitive decline. According to numerous clinical studies, this element called BioPQQ is proven to enhance brain health, performance, and longevity in consumers. How does BioPQQ achieve this? By increasing nerve growth factor and promoting the growth of new mitochondria. Both of these are vital to support healthy, functioning hearts and brains. BioPQQ just might be the solution for how to improve brain health.

In an effort to raise awareness about the importance of actively working to maintain brain health, Mitsubishi Gas Chemical America launched a video to provide education about the aging brain including shrinking brain cells and energy loss. Fortunately, seniors can protect themselves against the onslaught of cognitive decline and neurodegenerative diseases, and BioPQQ supplementation is just one way of being proactive. You can watch this video on how to improve brain health with BioPQQ by clicking here.

The Benefits of BioPQQ

Scientists have conducted multiple clinical studies which show that BioPQQ supplementation produces numerous positive benefits including increased word recall, improved short-term memory, lowered LDL cholesterol levels, better sleep, more energy, less stress, a higher learning ability, energy-building cell growth, and boosted nerve growth factor and mitochondrial biogenesis. The results of the clinical studies on BioPQQ showed no toxicity or adverse effects when tested on both animals and humans. BioPQQ offers an easy solution for how to improve brain health.

BioPQQ Interview

I had the distinct honor and privilege of conducting an interview with Shoji Matsukawa, regarding how to improve brain health with BioPQQ. Shoji is the general manager of organic chemicals sales & marketing for Mitsubishi Gas Chemical America, the manufacturers of BioPQQ®.

Kaitlin: What is BioPQQ®?

Shoji Matsukawa: BioPQQ® is a safe, all-natural supplement ingredient that supports heart and brain health. The ingredient supports cognitive health by boosting nerve growth factor in the brain as well as the creation of mitochondria, which is critical to brain and heart function. By functioning as a superior anti-oxidant, BioPQQ® has also shown to inhibit neurotoxicity. Its antioxidative effects have been demonstrated to be significantly higher than both Vitamin C and Vitamin E.The supplement is a natural source of pyrroloquinoline quinone and manufactured in Japan by Mitsubishi Gas Chemical Co. Inc. to food-grade standards. BioPQQ is the only one of its kind with a New Dietary Ingredient (NDI) notification by the U.S. Food and Drug Administration and GRAS (Generally Recognized as Safe) status, enabling it to be included as a food ingredient. With MGC’s commitment to pioneer an effort for more clinical data and research, BioPQQ® is also the most widely studied ingredient of its kind. Its safety has been evaluated in dozens of published animal and in-vitro and in-vivo human toxicity studies.

Kaitlin: How does BioPQQ protect mitochondria from stress and grow new mitochondria?

Shoji Matsukawa: Mitochondrial function can be directly linked to protection from certain chronic diseases and conditions, such as heart disease, diabetes, metabolic syndrome, and chronic inflammation. Mitochondrion loses energy as we age, leading to impaired memory function. BioPQQ® was found to affect the cell signaling pathways associated with oxidative metabolism, a key factor in cellular aging processes, and in mitochondrial biogenesis—the production and growth of new mitochondria, the energy generating “powerhouses” of cells. For example, one study reported that rats fed a BioPQQ®-supplemented diet showed better learning ability than controls, suggesting that BioPQQ® may be useful for improving memory in humans. Research also explores how gene expression signaling pathways may be affected by BioPQQ-enhanced mitochondrial biogenesis. Overall, these clinical and in-vitro studies show that BioPQQ® works against the causes of mitochondrial decline. Antioxidant substances and food ingredients that remove active oxygen have been shown to improve brain function in memory and learning. BioPQQ® has robust antioxidant effects which potentially protect neurons in the brain that are susceptible to lethal damage from oxidative stress. BioPQQ® may also help protect neurons from potentially harmful oxidative stress by potentially stimulating Nerve Growth Factor (NGF).

Kaitlin: I understand that BioPQQ® boosts nerve growth factor. Could you please tell us more?

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Shoji Matsukawa: In addition to acting as an antioxidant, BioPQQ® can facilitate nerve regeneration. Research supports that through the stimulation of NGF, BioPQQ® may help nerves in the brain and other organs grow or recover after being damaged. As suggested in dozens of in-vitro and in vivo clinical studies and trials, BioPQQ® may have significant physiological benefits for heart and
brain health. For example, in a study conducted on mice, BioPQQ® showed the strongest activity of promoting nerve growth factor synthesis in cells, without causing cytotoxicity. In addition, in-vitro studies show BioPQQ® was found to be a potent enhancer of NGF production.

Kaitlin: What are the benefits of BioPQQ®?

Shoji Matsukawa: Clinical studies have shown that incorporating BioPQQ® into one’s diet can have many positive benefits, including increasing word recall, improving short-term memory, maintaining low cholesterol levels, better skin conditions, better sleep, more energy, and less stress. BioPQQ® has
also been shown to improve learning ability, activate energy-building cell growth and increase NGF and mitochondrial biogenesis.

Kaitlin: Could you please tell us more about BioPQQ®’s clinical studies and their success?

Shoji Matsukawa: As BioPQQ® is the most clinically tested supplement of its kind, there are a plethora of studies available attesting to its efficacy and safety. BioPQQ® has been tested on animals and humans, with studies showing it has no toxicity or adverse effects. In-vitro studies show boosted NGF, activation of energy-building cell growth and extended life span of C. elegans. The studies also show taking the supplement may help nerves in the brain and other organs grow or recover after being damaged. Animal studies show higher learning ability and improved memory and rebuilding of cells, immune system, and brain function.

In addition, results of a touch-M cognitive function test show that senior citizens taking 20mg/day of BioPQQ® experienced significant improvement in cognitive function. Results for the Mood States cognitive function test also show adults taking 20 mg/day of BioPQQ® experienced significant improvements in vigor, fatigue, tension-anxiety, depression, anger-hostility, confusion, and sleep. Patients’ scores on Stroop cognitive tests were significantly better after intake of 20 mg of BioPQQ® over 12 weeks.

Kaitlin: Are there any medical conditions with which a patient shouldn’t take BioPQQ®?

Shoji Matsukawa: BioPQQ is not intended for children, pregnant or lactating women. Adverse effects on specific diseases are not known, but those who are undergoing treatment for a medical condition should consult a physician.

Kaitlin: What does the process of harvesting the active ingredient in BioPQQ® look like?

Shoji Matsukawa: BioPQQ® is harvested through a proprietary natural fermentation process by scientists at Mitsubishi Gas Chemical following the highest standards for purity, which was established through its extensive research spanning more than 30 years. The ingredient is found naturally in
some plants and animals.

Kaitlin: Is there anything else you would like to tell us about BioPQQ?

Shoji Matsukawa: BioPQQ® is included on the European Union’s list of Novel Foods, the first ingredient of its kind in the European market. In August 2018, BioPQQ® earned Informed-Choice and Informed-Sport certification, attesting that the product is manufactured to high-quality standards and has been
tested for substances that are prohibited in sports. BioPQQ® is not intended to diagnose, treat, cure or prevent any disease.


In conclusion, learning how to improve brain health is a necessary yet complicated process. BioPQQ can help to simplify your brain health support regimen because nothing is easier than taking a supplement! To learn more about how to improve brain health with BioPQQ, please visit their website here!