Research shows that Grape seed extract can kill at least 3 cancers
Grape seed extract is a well known source of powerful antioxidants, which are compounds widely studied and proven to have anticancer properties. So, below are some scientific studies proving that Grape seed extract can kill at least 3 cancers.
The secret in grapes is something called resveratrol, an antioxidant reported to provide many health benefits, including chemoprevention. Scientists were able to observe, through many studies that Grape seed extract can kill at least 3 cancers, namely skin cancer, prostate cancer, and breast cancer. Below are some of the promising findings.
Skin cancer seems to be a world epidemic, with 132,000 melanoma skin cancers diagnosed every year, according to The World Health Organization. So, knowing about natural products that can help reduce these numbers is good news to say the least. Two studies showed promising results with the usage of GSE to prevent or kill cancer.
The first study was designed to assess the anti-tumour promoting effect of Grape seed extract (GSE) polyphenolic fraction. Scientists found that, topical Grape Seed polyphenolic (GSP) fraction reduced significantly tumor incidence, tumor multiplicity and tumor volume.
The second animal model study, where carcinogenesis was induced by UVB radiation, concluded that dietary feeding of GSP was effective in preventing photocarcinogenesis at both initiation and promotion stages and malignant transformation of skin papilomas to carcinomas.
Prostate cancer is one of the most commonly diagnosed cancer in men, but results of an in vitro study, using prostate cancer cells (DU145 cell line ) exposed to Grape seed extract, showed that GSE caused aptosis or the death of prostate cancer cells. It was observed that GSE exerts antiproliferative and antiangiogenic effects.
In other studies, GPE was observed to inhibit the nuclear factor-kB (NF-kB) pathway and thus causes the death of DU145 cells.
Breast cancer has a higher mortality, if compared with other cancers plaguing the world in modern medical history. So, scientists have been exploring ways to develop effective therapeutic approaches to conquer breast cancer malignancy. The exploring of options has led scientists to research procyanidin dimmers from wine extract, which are also found in high quantities in grape seeds. Researchers were able to observe that procyanidin B2 dimer inhibits the activity of aromatase, an enzyme that is highly expressed in cancerous breast tissue.
In vitro studies, observed that GSE has antiangiogenic effects on breast cancer cell lines (MDA-MB-231), meaning that GSE is able to inhibit the proliferation of breast cancer cells.
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