Grape Seed Extract (GSE) proven to be a new treatment for Haemochromatosis

Grape seed extract a new hope for Haemochromatosis sufferers

Recent research has suggested that conditions caused by Haemochromatosis can be improved by simply taking GSE as a dietary supplement.

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The “secret” is that GSE is packed with polyphenols, including gallic acid, catechin, epigallocatechin gallate (EGCG) and proanthocyanidins. These, work in the body as antioxidants, which come from their ability to scavange free radicals and chelate metals. Making GSE a potential way to treat haemochromatosis

Haemochromatosis is a genetic inherited disease that causes one’s body to be overloaded by Iron. According to the Centers for Disease Control, it is one of the most common genetic disorders in The United States and people of Northern European descent have a higher chance of having an altered HFE gene.

Iron overloading has an oxidative effect on the patient, because if iron accumulates abnormally in the hemoglobyn (the cells responsible for transporting oxygen), it accelerates the degradation of body tissues.

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Some of the early symptoms of Haemochromatosis include: fatigue, sore joints, frequent infections and as the iron builds up in the liver, heart disease, spleen, and pancreas – it tends to destroy cells, causing cancer, atherosclerosis, liver cirrhosis, neurological disease, and other disorders. The current medical procedure for Haemochromatosis treatment is called phlebotomy, which consists of removing up to 500ml of blood at regular intervals, roughly three to four times a year. A balanced diet consisting of low iron foods is also required.

In a series of studies conducted in animals and humans, it was found that “…GSPE (grape seed proanthocyanidin extract) supplementation improved cardiac functional assessment including post-ischemic left ventricular function, reduced myocardial infarct size, reduced ventricular fibrillation (VF) and tachycardia...”(1 ) In another study, the use of GSE and EGCG inhibited nonheme iron absorption in human intestinal Caco-2 cells by reducing basolateral iron exit via FPN-1 rather than by decreasing apical iron import (2). For people who develop atherosclerosis for example, the supplementation of a meal with GSE minimizes the postprandial oxidative stress by decreasing the oxidants and increasing the antioxidant levels in plasma…”(3).

The Iron Disorder Institute explains that caucasians are most at risk for the classic type of Haemochromatosis. So, Lack of energy, abdominal pain, Memory fog, Loss of sex drive, heart flutters and Irregular heart - beat should not be overlooked. A simple blood test can confirm or rule out Haemochromatosis. If diagnosed at early stages a person can live a normal, healthy life.

Reference

  • Bagchi D, Sen CK, Ray SD, et al. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutat. Res. 2003;523–524:87–97.
  • Kim EY, Ham SK, Shigenaga MK, Han O. Bioactive dietary polyphenolic compounds reduce nonheme iron transport across human intestinal cell monolayers. J. Nutr. 2008;138:1647–1651.
  • Natella F, Belelli F, Gentili V, et al. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric Food Chem. 2002;50(26):7720-5

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