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New Drug Can Help Combat Obesity May Help Diabetes

Weight Loss and Obesity

Researches have been working on finding ways to help people with obesity. Recently they released information about a new drug that can help combat obesity and it may help diabetes. Scientist has developed a drug that apparently made mice lose weight and they claimed it “reversed” diabetes and lowers cholesterol. It is called Fatostatin.

A new drug that can help combat obesity and may help diabetes could be good news since the obesity rate in American is rising at a steady pace. Currently statistics are suggesting that 2/3 of American are either overweight or obese. An estimated 300,000 deaths per year may be attributable to obesity. People who are overweight can suffer from diseases such as heart problems, high cholesterol, diabetes, and run the risk for certain types of cancer including colon, gall bladder, prostate, kidney, and breast cancer.

A weight gain of simply 11-18 pounds increases the risk of type-2 diabetes and a weight gain of 20 pounds in women cans double their risk for breast cancer. For every 2-pound increase in weight, the chance of developing arthritis is increased by 9 to 13%.

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The new drug that that can help combat obesity and it may help diabetes is being named Fatostatin. It seems to be able to stop the body from making fat, instead of releasing the energy from food. Scientists are hoping that this may eventually lead to a pill that would fight obesity, diabetes and cholesterol. Writing in the journal Chemistry and Biology, Salih Wakil of Baylor College of Medicine in Texas, Motonari Uesugi of Kyoto University in Japan and colleagues said the drug interferes with a suite of genes turned on by overeating.

Fatostatin is a small molecule, which means that it has the potential to be absorbed in pill form. They way it works is on a sterol regulatory element binding proteins or SREBPs, which can activate genes involved in making cholesterol and fatty acids. "Fatostatin blocked increases in body weight, blood glucose, and hepatic (liver) fat accumulation in (genetically) obese mice, even under uncontrolled food intake," the researchers wrote.

A new drug that that can help combat obesity and it may help diabetes could reduce diseases. In fact, weight loss, as minor as 5 to 15% of total body weight in a person who is overweight or obese, reduces the risk factors for some diseases. Fatostatin could have the ability to help change some of the dramatic obesity statistic in the United States.

Obesity and Diabetes Info
US Dept of Health and Human Services