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Progressive Multiple Sclerosis Responds to Biotin

progressive multiple sclerosis responds to biotin

High doses of biotin, which is also known as vitamin H, were associated with improvements in disability among patients with progressive multiple sclerosis. The results of this latest study, which follows on the heels of another research endeavor concerning biotin for multiple sclerosis, will be presented at the American Academy of Neurology annual meeting on April 24, 2015.


The phase III placebo-controlled trial involved 154 patients with progressive multiple sclerosis who were given either 300 mg per day of biotin (as the drug MD1003) or placebo for 48 weeks. The usual recommended daily dose of biotin is 30 to 100 micrograms (mcg) daily.

All the participants were evaluated at 9 months and 12 months. Improvement was defined as either a decline in the Expanded Disability Status Scale (EDSS) of at least 1 point for patients who had a baseline EDSS of 5.5 or less and 0.5 points for those with an EDSS of 6 or greater, or who showed an improvement of 20 percent or more on a timed 25-foot walk.

Why biotin? This vitamin is a coenzyme for carboxylases, enzymes that play a critical role in energy metabolism and the production of fatty acids. In particular, biotin activates acetylCoA carboxylase, which is involved in the synthesis of myelin.

Therefore, it is proposed that biotin may help to slow, stop, or even reverse the progression of disability associated with demyelination. Demyelination is the loss of the myelin that protects the nerves and thus results in progressive loss of function.

According to a release from MedDay Pharmaceuticals, which makes the high-dose biotin drug, the result “suggests that MD1003 could be an important and efficacious treatment for primary and secondary progressive multiple sclerosis,” according to Professor Ayman Tourbah, of CHU de Reims, Neurology, France, and the principal investigator of the study.

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Previous biotin and multiple sclerosis study
A small uncontrolled pilot study (23 patients) administered 100 to 600 mg (mean, 300 mg) per day of biotin to patients with primary or secondary progressive multiple sclerosis. The patients were treated for a mean of 9.2 months (range, 2-36).

Here are the findings:

  • 4 patients who had prominent visual impairment associated with optic nerve injury experienced significant improvement in visual acuity
  • 1 patient with left homonymous hemianopia (blindness in more than 50% of field of vision) continued to improve from 2 to 16 months after treatment started
  • 16 of 18 (89%) patients with prominent spinal cord involvement improved, which was confirmed with blinded review of videotaped exam of 9 patients
  • The following signs and symptoms improved for the number of patients (in parentheses): fatigue (5), swallowing problems (4), unclear articulation of speech (dysarthria, 3), sensory signs (2), gait problems (2), urinary dysfunction (2), cognition (1), psychiatric signs (1), visual problem (oscillopia, 1), motor coordination (1), and Uhthoff’s phenomenon (1)
  • EDSS scores improved significantly in 22 percent of patients

(By way of disclosure, it should be noted that the CEO of MedDay, Frederic Sedel, MD, participated in the biotin research for multiple sclerosis reported here.)

Biotin has not been shown to be toxic. Doses up to 200,000 mcg/day (equal to 200 mg) have been tolerated in people who have hereditary disorders of biotin metabolism. In healthy individuals, doses of up to 5,000 mcg/day (5 mg) taken for two years resulted in no adverse effects.

Biotin is a new entry into the arena of potential treatment options for multiple sclerosis. Currently there are at least two clinical trials exploring the effects of biotin (MD1003) in multiple sclerosis.

Also read about fish oil for multiple sclerosis
5 nutrients low in women with multiple sclerosis
Alternative treatments for multiple sclerosis

Linus Pauling Institute
MedDay Pharmaceuticals
Sedel F et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study. Multiple Sclerosis and Related Disorders 2015 Mar; 4(2): 159-69



In the second paragraph you mention 300mg of biotin were given per day (this is 300,000mcg per day). Then you mention the daily dose of biotin is 30 to 100 micrograms (mcg) daily. Is that is typo in the first statement - should it read 300mcg per day?
Gerald. Thank you for the question. No, it is not a typo. The recommended daily dose of biotin (RDA) is 30 to 100 micrograms. The doses used in the studies were 300,000 mcg (300 mg). These two studies involved mega doses of biotin. As I also noted in the next to last paragraph, biotin has not been found to be toxic at high doses.
I'd like to know more about if this is true
Debbie, thanks for writing. Many people would like to know how effective biotin may be for progressive MS. Research is ongoing, and so time will tell. I will say, however, that I have had a few people who have MS write (in a different forum) who say they take high doses of biotin and it has provided some benefit. As with any treatment, response is highly individual.
Where can I buy biotin in high doses like 300 MG. or 300,000 mcg?
I have seen at least one well-known brand being sold online with 100,000 mcg. I cannot recommend any one brand, but look for ones that say super high potency. You also may try a compounding pharmacy.
My doctor is looking into the mega dose safety -- Biotin has been tested alot for various skin conditions, and its safety shold be relatively well understood from those applications.
Can you please keep my updated with MS related research and studies? Thank you
What is the delivery method for this drug? Also is the a estimate on when this drug would be going before the FDA for (possible) approval?
Can your tell me anything about the source of the Biotin. Was it Biotin USP powder?
Rocco. I do not know if the biotin was USP powder. It was provided by MedDay Pharmaceutical, and their website does not provide information about the form it takes. You might contact the company and ask about the formulation.
it does sound promising. so i would to be updated on the progress.
I interested in going on Biotin
My brother is interested in going on biotin. He is a general practitioner. We are searching for the recommended dose but we can't find it. Moreover,we cannot order biotin 100000 μg using credit cards from e- shops in foreign countries because of capital control in our banks. Is there any way , chance of getting biotin 100.000μg in Crete Greece and paying it on arrival. Thank you in advance for your response - help.
You can purchase biotin powder from purebulk.com and bulksupplements.com. You could phone or email them and ask if they take money orders or certified cheque instead of credit card.
You can delete the following if inappropriate: There is a Facebook group named; Biotin for Progressive MS Nearly 2000 members now and a lot of info about MS and Biotin.
Thank you for sharing this information with readers!
I am very interested in this development for Progressive MS. I would be particularly interested in finding out if a) I can be a participant in the study and b) where I can buy a higher dosage Biotin supplement at the highest I can find would mean taking 30 per day!
I discovered BIOTIN (I think they put it in all caps for marketing) five or six years ago. I have PPMS. I was drinking water flavored by various brands in tubes made to add to 500ml of water. Whenever I drank Wal-Mart brand of wild strawberry, I would feel a slight increase of feeling in my toes. After this happened more than a few times, I checked the ingredients. The only difference in the wild strawberry was the last ingredient listed, BIOTIN. I started taking 5,000 mcg a day (5 mg), why do they list it in thousands of mcg instead of mg? I guess marketing. It helped some with numbness/stiffness/gait for a while after taking it. Some seven to ten days later, it stopped helping. I stopped taking it. A few years later I read where the French were using it 100mg three times a day on progressive MS and getting good results. I bought twenty bottles of 10,000mcg of BIOTIN, and started taking one pill three times a day (I had checked with my primary care physician about taking vitamin B3. He said any excess would be eliminated in my urine, so go ahead and take them),; it helped for 7-10 days, then stopped so I increased it to two pills three times a day. It helped again, for about a week. I increased dosage to three pills three times a day. It helped, for about a week. This continued, and around the switch from six to seven pills three times a day, it stopped working. I then went to ten pills (100mg) three times a day...I did not experience the previous relief. I went ahead and took ten pills three times a day, I think they may have been helping a little. I stopped taking them when I had four bottles left because the relief wasn't worth the trouble, and in the future I can try taking them for some temporary relief.
To Whom It May Concern My name is Nick Kokokiris and I have secondary progressive Multiple Sclerosis. I live in Sydney, Australia and want to buy Biotin 100mg (50 tablets or more) for progressive Multiple Sclerosis. I would like to ask you a few questions; 1. Do you have Biotin 100mg (50 tablets or more) for progressive Multiple Sclerosis? 2. What is the cost to buy Biotin 100mg (50 tablets or more) for MS and the delivery costs to Sydney, Australia? 3. Is the cost quoted that you have given me in Australian dollars? 4. Do you deliver this product to Sydney, Australia? 5. Where are you located? 6. Do you accept credit card for payment of the tablets and for delivery? Please answer me the above questions before I buy anything. Kind regards Nick Kokokiris Thursday, 3rd November 2016
Hi Nick: We do not sell any products. We are a health news website only.
first time I heard of biotin was an ad new Zealand where the study began progressive that's when high dosages were made. I am spms and will take 100 mg or mg/d
Nick, did you ever find where to buy Biotin? I just purchased from a compound pharmacy named "ACE SP&C", recommended from my neurologist at Stanford University. You may want to look into it and see if you can have mailed to Australia.
hi Nick I just saw your post and was wondering if you found somewhere to buy the high dose of biotin I also have MS and am needing to take 300mg. if you could please let me know and thank-you very much for your time cheers Penny
I have RRMS, could I take this same amount? Is there a Biotin study for RRMS?
The study was for PPMS and SPMS only. There is no data for RRMS. You can read the study by looking up MD1003 trials.