How Resveratrol May Help Type 2 Diabetes
Resveratrol, a plant compound found in red grapes, red wine, and several other foods and beverages, has been touted as an antiaging supplement that may also support heart health. Now researchers associated with two different studies say resveratrol may help type 2 diabetes and improve quality of life if you are taking antidiabetes medication.
What experts discovered about resveratrol
Both studies explored the use of resveratrol along with conventional antidiabetes treatment. The study published in Evidence-Based Alternative and Complementary Medicine included 66 subjects with type 2 diabetes who were taking either metformin and/or glibenclamide, or metformin plus insulin.
The randomized, double-blind, placebo-controlled trial lasted 45 days, during which 33 individuals took 1 gram daily of resveratrol and 33 took a placebo. Compared with the measurements taken at the beginning of the study, those documented at the end of the trial showed the following:
• Patients who had taken resveratrol showed a significant decline in systolic blood pressure, fasting blood glucose, hemoglobin A1c (HbA1c), insulin, and insulin resistance.
• Patients who took resveratrol also showed a significant increase in high-density lipoprotein (HDL) cholesterol
• Patients in the control group, however, experienced a slight increase in their fasting glucose and low-density lipoprotein (LDL) cholesterol compared with baseline
Based on these findings, the authors concluded that “Overall, this study showed that resveratrol supplementation exerted strong antidiabetes effects in patients with type 2 diabetes.”
Those were the results of one study, but what did the other team of researchers discover about resveratrol? In the second study, 57 patients who were taking metformin and/or glibenclamide participated in a six-month trial.
Half of the individuals took 250 mg per day of resveratrol while the other half took a placebo. After six months, here’s what the researchers found:
• Patients who took resveratrol showed a significant change in body weight, body mass index, systolic blood pressure, total cholesterol and triglyceride levels, and two other diabetes markers—urea nitrogen and total protein levels
• No significant change was seen in fasting blood glucose or hemoglobin A1c levels among resveratrol users when compared with controls, although there was a slight improvement in both values
• Users of resveratrol also showed significant changes in superoxide dismutase, catalase, and glutathione, three substances that play an important role in type 2 diabetes
The authors of this second study concluded that “resveratrol supplementation may improve the associated risk factors and glycemic control in patients with T2DM [type 2 diabetes mellitus]” and that “resveratrol can, therefore, be used as an effective adjuvant therapy” along with conventional antidiabetes medications.
If you have type 2 diabetes, would you like a chance to improve your quality of life? If so, then you should ask your healthcare provider about taking resveratrol supplements.
Kumar BJ, Joghee NM. Resveratrol supplementation in patients with type 2 diabetes mellitus: prospective, open label, randomized control trial. International Research Journal of Pharmacy 2013; 4(8): 245-49
Movahed A et al. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Evidence Based Alternative and Complementary Medicine 2013; 2013(851267)