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Excessive sweating study searches for connection to antidepressants

Lana Bandoim's picture

A new study is searching for a connection between excessive sweating and antidepressants. Researchers at Thomas Jefferson University in Philadelphia are conducting a clinical trial and testing the use of glycopyrrolate as a treatment. Excessive sweating can be an embarrassing condition that limits some people’s social interactions.


Excessive sweating or hyperhidrosis may be caused by several medical conditions, but there are instances of people suffering from this problem without any other health issues. It is estimated that 8 million people in the United States have hyperhidrosis, and they are left wondering how to sweat less and eliminate this embarrassing problem.

Excessive sweating can be caused by anxiety, cancer, diabetes, heart disease, hyperthyroidism and other medical conditions. Diabetes and hyperthyroidism are considered to be some of the most widespread reasons for sweating too much, but it is possible to suffer from other health problems unrelated to these two disorders.

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Medications have also been linked to excessive sweating, and the problem has been blamed on certain antibiotics and supplements. In addition, research on antidepressants has found that some are capable of causing hyperhidrosis. A study published by the American Academy of Clinical Psychiatrists reveals that antidepressant-induced excessive sweating (ADIES) may be treated with terazosin. Patients complained about sweating too much from their face, scalp, neck and chest after taking antidepressants, but terazosin provided relief.

A double-blind, placebo-controlled study from researchers around the globe focused on patients who were taking the antidepressant sertraline. A group of 140 patients received oxybutynin as a treatment, and scientists noted a reduction in excessive sweating. However, they mentioned women benefited from the treatment more than men.

Now, a new study from Thomas Jefferson University is searching for answers. Researchers are in the first phase of the clinical trial and are still recruiting participants. They are searching for people who are at least 18 years old, suffer from excessive sweating and take antidepressants. They hope to discover if glycopyrrolate can be an effective treatment during eight weeks of testing. Glycopyrrolate, also known as Robinul, is generally used for the treatment of ulcers, but it has been used to stop severe drooling in some patients.