BPA Linked to Increased Testosterone Levels in Men
Increasing evidence of endocrine effects on humans from bisphenol A (BPA) continue to accumulate. The latest comes from a study reported in Environmental Health Perspectives which links BPA exposure to higher testosterone levels in men.
How research measured BPA concentration
Tamara Galloway, PhD, of the University of Exeter in England, and colleagues conducted a random sample study of 715 adults 20 to 74. BPA concentrations were measured by liquid chromatography mass spectrometry (LC-MS) in 24 hour urine samples provided by each participant.
Bisphenol A is a high production volume chemical widely used in food and drinks packaging. There are numerous studies which demonstrate that BPA can alter endocrine function in animals. This is one of the few human studies.
The researchers set the principal outcomes as serum concentrations of total testosterone and 17 beta-estradiol.
The geometric mean urinary BPA concentration was 3.59 ng/mL, and daily excretion averaged 5.63 µg. Higher excretion was associated with male sex, younger age, greater waist circumference and weight.
Women had significantly lower BPA excretion compared with men, as did the older participants.
BPA excretion had a significant association with total testosterone (P=0.004) but not 17 beta-estradiol. Further analysis did show a significant association between BPA excretion and sex hormone binding globulin in the 60 premenopausal women.
The authors acknowledged the need for validation in other independent populations, use of a single 24-hour BPA excretion rate, and the cross-sectional nature of the study.
Galloway T et al "Daily bisphenol A excretion and ssociations with sex hormone concentrations: results from the InCHIANTI adult population study" Environ Health Perspect 2010; DOI:10.1289/ehp.1002367.