Pfizer Buys Right To Xiaflex For Bent Penises, Fingers Treatment

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Pfizer has bought the rights to Xiaflex from Auxilium Pharmaceuticals. Under the agreement, Pfizer will pay Auxilium $75 million upfront and to $410 million for the rights to the drug. Auxilium will receive increased royalties bases on sales in sales of the drug in Pfizer's territories.

Xiaflex, clostridial collagenase given by injection, is an investigational new drug that has completed phase III clinical trials for the treatment of Dupuytren's contracture. It is in Phase IIb of development for the treatment of Peyronie's disease and is in Phase II of development for the treatment of Frozen Shoulder syndrome (Adhesive Capsulitis).

Xiaflex would provide a non-surgical treatment for these conditions. The drug is a combination of several subtypes of collagenase, derived from clostridium histolyticum. Together, they work synergistically to break the bonds of the triple helix collagen structure more effectively than human collagenase.

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In Dupuytren's contracture, there is a build up of collagen in the palm and fingers, forming knots and cords of tissue under the skin. As the cords thicken, they can pull the fingers into a bent position. This will then prevent the finger from being able to straighten completely and impair function of the hand. Up to 3% of whites, usually of Northern European ancestry, may be affected by this disease.

Peyronie's disease is a condition of uncertain cause. It is characterized by a plaque or hard lump of abnormal collagen that forms on the penis. The plaque develops on the upper or lower side of the penis in layers containing erectile tissue. As this collagen tissue thickens, the penis bends to one side in a curved position. This then makes intercourse difficult and often painful. This may occur in up to 1% of men.

Frozen Shoulder syndrome is also know as adhesive capsulitis. It is characterized by pain and stiffness in the shoulder joint. The collagen in the scar tissue limits the shoulder's range of motion. Frozen shoulder usually affects one shoulder at a time, although some people may eventually develop frozen shoulder in the opposite shoulder.

Sources:
* Auxilium Pharmaceuticals, Inc. and Pfizer Enter Agreement to Develop and Commercialize XIAFLEX(TM) in Europe (Press Release)
* Pfizer Buys Rights to a Drug to Fix a Curved Penis (Pharmalot.com)

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