What researchers discovered about Crohn's disease in the past year

Dec 31 2013 - 11:36am
This year has brought many advances for understanding Crohn's disease.

Autoimmune diseases like Crohn’s are poorly understood by researchers. Scientists are still uncertain about how the body’s immune system attacks perfectly healthy cells to lead to disease like type 1 diabetes, lupus, Crohn’s disease, multiple sclerosis and more. But 2013 has lead to some advances in understanding Crohn’s disease that can lead to better treatment and improved quality of life for those suffering from the condition that can be debilitating.

Understanding Crohn’s disease with fibrosis

Researchers from University of Bristol uncovered the culprit for scarring and hardening of the intestines that can happen with Crohn’s disease and often requires surgery.

Fibrosis causes the intestines to narrow and become thick so nutrients cannot be absorbed and feces can no longer pass.

In their study, the scientists isolated a protein known as IL-13 that is overly expressed that promotes Crohn’s disease fibrosis. The result of the finding will lead to better therapies for the disease that can be started before fibrosis and the need for surgery occurs. The finding was published in the journal PLoS ONE in December, 2012.

New drug therapy on the horizon for Crohn’s disease?

The drug Vedolizumab is currently under development for treating Crohn’s disease.

One of the important highlights of the medication should it pass approval is that preliminary studies show it delivers targeted treatment to stop the inflammatory process that happens with Crohn’s disease and ulcerative colitis, both of which are are forms of inflammatory autoimmune diseases that affect the small intestine and colon.

Current treatments help Crohn’s disease, but with potentially serious side effects such as risk of infection, weight gain and blood sugar elevation that can come from taking steroids. Immunosuppressive medications can also make people more vulnerable to infection and are associated with lymphoma.

William Sandborn, MD, principal investigator of the Crohn's disease study, said the clinical trials so far offer new hope to the more than one million Americans who suffer from inflammatory bowel disease (IBD) and do not respond to treatment. Two studies showed vedolizumab induced remission of the disease that allowed participants to stop taking prednisone.

Genes found for Crohn’s disease

More than 200 genes were found in the past year that can contribute to Crohn’s disease.

Findings from researchers at University College London, published in The American Journal of Human Genetics is also an advance for understanding how treatment for Crohn’s disease can be personalized.

Dr Nikolas Maniatis, senior author from the UCL Research Department of Genetics, Evolution and Environment, said in a press release: "The discovery of so many gene locations for Crohn's Disease is an important step forward in understanding the disease, which has a very complicated genetic basis.”


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The researchers said finding so many genes associated with Crohn’s disease helps explain why the disease doesn’t act the same for everyone that will in turn make treatment more individualized.

A potential cause for Crohn’s disease

A study published in the journal Clinical and Translational Gastroenterology found a potential cause for Crohn’s disease, though more studies are needed to confirm that a virus may be responsible.

In June, 2013, researchers from Uppsala University announced for the first time that they found a link between all children with Crohn’s disease and an enterovirus (intestinal virus). The scientists are pursuing the possibility that enterovirus may be an underlying cause for the inflammatory bowel disease.

New treatment guidelines for Crohn’s this year

The American Gastroenterological Society updated guidelines for treating Crohn’s disease this year. Experts recommend using biological therapies first for moderately severe cases of Crohn’s disease.

The impetus for the guidelines was a combination of patient preferences for Crohn’s treatment, clinical evidence about what works and what doesn’t and risk and benefits of various treatments.

What do Crohn’s disease patients need in 2014?

EmaxHealth had an opportunity to interview Jennifer Hope who runs a Crohn’s disease forum (Crohnsforum.com)


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i look forward to hearing any new information on Crohns. it is such a difficult illness to live with!
Jackie, we feel the same way here at EmaxHealth, which is one of the reasons we have been looking for new research and other treatments. There are diseases that get more focus than others and more funding for research. Of course, finding the cause and knowing how to prevent it completely would be the absolute best! Then for those who have it, an absolute cure. Thank you for your comment.
In reference to the enterovirus, does that mean a virus you have in childhood(like a stomach virus) or does that mean a virus that lives within the intestines of the child?
My husband has been battling chrons/ultra colotits since 2005 he see a GI Dr and was diagnosed with this disease there at first he was getting his meds. Now since we can't afford the dr office fees he won't give him anymore meds. He has to have the steroids if not he will get inflamed he has so much abdominal pain what do we do
Hi Linda - according to the study authors, the intestines seemed to be compromised from either persistent infection or one that keep recurring.
Oh Angela, I am so sorry. If the problem is not getting to the doctor, please consider speaking with their financial (billing) office to work out a payment plan. Most doctor's offices are more than willing to do that. Can you tell me if your husband has health insurance?
This was an interesting read for the most part, however id say that its not new knowledge to say that this disease is very individualistic and its hard to find treatment that works. In regard to pamphlets and such? Most areas have a chapter of the CCFA in their areas and I know from experience that they provide all the informational pamphlets you could hope for. They even had ones directed towards teachers that I gave to each of mine while I was in school for understanding and coping with your student. Someone commented about costs of meds on here and I know how that goes. I can only take one anti-acid and of course its not covered. You can usually go to the drugs website and print out coupons/savings cards. I've done that multpile times and have paid either very little or nothing at all, their pretty great.
Anyone been taking Azathioprine and experienced muscle wasting? Done with that drug!!! Dangerous and doctors treat you like, oh well!!