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Natural S-equol supplement reduces hot flashes

Kathleen Blanchard's picture

A new compound developed from a germ-based soy ingredient has been shown to reduce hot flashes in menopausal women by fifty nine percent. The hot flash supplement, SE5-OH containing Natural S-equol, was studied in US and Japanese women, and shown to reduce symptoms of menopause, including hot flashes, because it binds with estrogen receptors in the body.

According to Belinda H. Jenks, Ph.D., director of Scientific Affairs & Nutrition Education at Pharmavite LLC, "Natural S-equol, a soy-derived compound that is thought to interact with specific estrogen receptors, has been studied for its benefits in relieving menopausal symptoms in both U.S. and Japanese women.. The data presented at NAMS adds to this research and illustrates the potential that SE5-OH containing Natural S-equol has for management of menopausal symptoms.”

The researchers explain how daidzein, a compound in soybeans, can be metabolized with the help of intestinal bacteria. Once digested, the body converts daidzein into Natural S-equol, a compound thought to act as a selective estrogen receptor modulator (SERM). SERMs have the ability to bind to estrogen receptors.

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Soy has been known to improve menopause symptoms, but not for every woman. The body has to have the right digestive bacteria to make equol. The natural S-equol containing SE5-OH supplements are made from soy germ fermented with Lactococcus garvieae 20-92, increasing bioavailability.

According to Kenneth D. R. Setchell, Ph.D., professor in the Division of Pathology and Laboratory Investigation, Department of Pediatrics, Cincinnati Children's Hospital Medical Center in Ohio says, …”the SE5-OH Natural S-equol supplement offers a means of providing S-equol to those adults that do not produce it after ingestion of soy."

The natural S-equol supplement was not shown to produce hormone changes in the women studied, measured by lab tests. The natural S-equol supplement, in development by Pharmavite LLC, could prove to be a genuine natural remedy for hot flashes, without the worry of hormone replacement therapy. The study was presented at the North American Menopause Society (NAMS) 20th annual meeting.

Reference: NAMS